rs17098707
From SNPedia
| Merged into | rs2230345 |
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | common in complete genomics |
| Make rs17098707(A;T) |
| Make rs17098707(T;T) |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 119326585 |
| Gene | GRK5 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs17098707 |
| dbSNP (classic) | rs17098707 |
| ClinGen | rs17098707 |
| ebi | rs17098707 |
| HLI | rs17098707 |
| Exac | rs17098707 |
| Gnomad | rs17098707 |
| Varsome | rs17098707 |
| LitVar | rs17098707 |
| Map | rs17098707 |
| PheGenI | rs17098707 |
| Biobank | rs17098707 |
| 1000 genomes | rs17098707 |
| hgdp | rs17098707 |
| ensembl | rs17098707 |
| geneview | rs17098707 |
| scholar | rs17098707 |
| rs17098707 | |
| pharmgkb | rs17098707 |
| gwascentral | rs17098707 |
| openSNP | rs17098707 |
| 23andMe | rs17098707 |
| SNPshot | rs17098707 |
| SNPdbe | rs17098707 |
| MSV3d | rs17098707 |
| GWAS Ctlg | rs17098707 |
| Status | Merged into rs2230345 |
| GMAF | 0.0879 |
| Max Magnitude | 0 |
| ? | (A;A) (A;T) (T;T) | 28 |
|---|---|---|
|
| ||
This polymorphism is present in the GRK5 gene found on chromosome 10 and leads to a nonsynonymous change at amino acid 41 (Gln41Leu). The Leu change is more common in African Americans and less common in Europeans. The GRK5-Leu41 was associated with a decreased mortality in African Americans with heart failure or cardiac ischemia([PMID 18425130
]).
[PMID 16385451] A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
[PMID 19842931] GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans.
