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rs1726866

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0.1 can taste bitter
(C;T) 0.1 can taste bitter
(T;T) 1.1 possible unable to taste bitter
ReferenceGRCh38 38.1/141
Chromosome7
Position141972905
GeneTAS2R38
is asnp
is mentioned by
dbSNPrs1726866
dbSNP (classic)rs1726866
ClinGenrs1726866
ebirs1726866
HLIrs1726866
Exacrs1726866
Gnomadrs1726866
Varsomers1726866
LitVarrs1726866
Maprs1726866
PheGenIrs1726866
Biobankrs1726866
1000 genomesrs1726866
hgdprs1726866
ensemblrs1726866
geneviewrs1726866
scholarrs1726866
googlers1726866
pharmgkbrs1726866
gwascentralrs1726866
openSNPrs1726866
23andMers1726866
SNPshotrs1726866
SNPdbers1726866
MSV3drs1726866
GWAS Ctlgrs1726866
GMAF0.4082
Max Magnitude1.1
? (C;C) (C;T) (T;T) 28


rs1726866 is one of three SNPs that form the main haplotypes behind the ability to perceive as bitter the taste of the compound phenylthiocarbamide (PTC) and similar molecules in foods (like cabbage and raw broccoli) or drinks (like coffee and dark beers).

The rs1726866(C) allele is the "tasting" allele, and it is dominant to the "non-tasting" allele rs1726866(T), so having one copy is enough to have the bitter tasting ability. If you are a "taster", you're also likely to carry at least one rs713598(G) and one rs10246939(C) allele since, along with rs1726866(C), these three SNPs form the most common tasting haplotype. If you lack these alleles, you're quite likely (~80%) to be a non-taster of bitterness, meaning that foods that may taste bitter to others taste far less bitter to you.[PMID 12595690]

[PMID 19782709OA-icon.png] (C;C) women showed a lower tendency to overeat. (T;T) women showed a greater tendency to overeat.

OMIM607751
DescTASTE RECEPTOR, TYPE 2, MEMBER 38; TAS2R38
Variant
Relatedalso
OMIM607751
Desc
Variant0002
Relatedalso


ClinVar
Risk Rs1726866(T;T)
Alt Rs1726866(T;T)
Reference Rs1726866(C;C)
Significance Drug-response
Disease Phenylthiocarbamide tasting
Variation info
Gene TAS2R38
CLNDBN Phenylthiocarbamide tasting
Reversed 1
HGVS NC_000007.13:g.141672705G\x3d
CLNSRC OMIM Allelic Variant
CLNACC RCV000003039.1,



[PMID 15883422] TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study.


[PMID 18248681OA-icon.png] Prevalence of common disease-associated variants in Asian Indians.


[PMID 18834969OA-icon.png] A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.


[PMID 19092995OA-icon.png] Bitter taste receptors influence glucose homeostasis.


[PMID 19779476OA-icon.png] Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children.


[PMID 24083639OA-icon.png] Variations in Bitter-Taste Receptor Genes, Dietary Intake, and Colorectal Adenoma Risk


[PMID 23133589OA-icon.png] Bitter taste receptor polymorphisms and human aging.


[PMID 25257701OA-icon.png] Polymorphisms in TRPV1 and TAS2Rs associate with sensations from sampled ethanol


[PMID 32392191] [Genetic Predisposition to Early Myocardial Infarction].