rs17388568

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)		1.6x risk of type-1 diabetes
(A;G)		1.3x risk of type-1 diabetes
(G;G)	0	normal

Reference

GRCh38 38.1/141

Chromosome

4

Position

122408207

Gene

ADAD1

is a	snp
is	mentioned by
dbSNP	rs17388568
dbSNP (classic)	rs17388568
ClinGen	rs17388568
ebi	rs17388568
HLI	rs17388568
Exac	rs17388568
Gnomad	rs17388568
Varsome	rs17388568
LitVar	rs17388568
Map	rs17388568
PheGenI	rs17388568
Biobank	rs17388568
1000 genomes	rs17388568
hgdp	rs17388568
ensembl	rs17388568
geneview	rs17388568
scholar	rs17388568
google	rs17388568
pharmgkb	rs17388568
gwascentral	rs17388568
openSNP	rs17388568
23andMe	rs17388568
SNPshot	rs17388568
SNPdbe	rs17388568
MSV3d	rs17388568
GWAS Ctlg	rs17388568

GMAF

0.1726

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

rs17388568 has been reported in a large study to be associated with type-1 diabetes.

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.26 (CI 1.11-1.42), and for homozygotes, 1.58 (CI 1.27-1.95). [PMID 17554300]

In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.11 (CI 1.05–1.18). [PMID 17554260]

GWAS
SNP	rs17388568
PubMedID	[PMID 17554300]
Condition	Type 1 diabetes
Gene	NR
Risk Allele	A
pValue	3.00E-006
OR	1.26
95% CI	1.11-1.42

OMIM	612622
Desc	DIABETES MELLITUS, INSULIN-DEPENDENT, 23; IDDM23
Variant
Related	also

OMIM	222100
Desc	DIABETES MELLITUS, INSULIN-DEPENDENT; IDDM
Variant
Related	also

[PMID 20184734] The 4q27 locus and familial prostate cancer risk

[PMID 20553587] Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance

GWAS snp
PMID	[PMID 21297633]
Trait
Title	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Risk Allele	A
P-val	9E-7
Odds Ratio	1.1200 [1.07-1.17]

GWAS snp
PMID	[PMID 21829393]
Trait
Title	Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
Risk Allele	A
P-val	0.000006
Odds Ratio	1.1000 [NR]

[PMID 18369459] A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.

[PMID 19140132] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.

[PMID 19201773] Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.

[PMID 19359276] Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

[PMID 19639606] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.

[PMID 20722033] The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

[PMID 21875375] Study of polymorphisms in 4q27, 10p15, and 22q13 regions in autoantibodies stratified type 1 diabetes patients.

GWAS snp
PMID	[PMID 23817569]
Trait	Self-reported allergy
Title	A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
Risk Allele	A
P-val	4E-8
Odds Ratio	.07 [0.047-0.099] unit increase