Have questions? Visit https://www.reddit.com/r/SNPedia

Type-1 diabetes

From SNPedia

Wikipedia's article on type-1 diabetes (T1D) is a good starting point.

The article at emedicine is written by a doctor for a general audience, and omim provides a summary for researchers.

Classically, the highest risk factor for type-1 diabetes is associated with HLA genotypes DR3/4 and DQ8. SNPs rs2040410 and rs7454108 encode the corresponding alleles, and a genoset (Gs121) evaluates Promethease users to assess whether they are DR3/4 or DQ8 carriers.

Genes likely to affect susceptibility include the following. [PMID 19430480]

Many other SNPs may contribute to the likelihood and severity of type-1 diabetes, including:

  • rs7574865 is associated with type-1 diabetes in addition to multiple autoimmune disorders such as rheumatoid arthritis and lupus
  • rs3772534 has been reported to increase the risk of T1D (type 1 diabetes) in a Danish population studied, but in a larger English study, this did not replicate [PMID 17209142]

Islet transplantation seems to be emerging as an effective treatment [1]

Type 1 Diabetes

NEJM Shared and Distinct Genetic Variants in type-1 diabetes and celiac disease

DeCode reports that the following SNPs also contribute to susceptibility to T1D: