rs3024505
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 |
| Make rs3024505(C;T) |
| Make rs3024505(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 206766559 |
| Gene | IL10 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3024505 |
| dbSNP (classic) | rs3024505 |
| ClinGen | rs3024505 |
| ebi | rs3024505 |
| HLI | rs3024505 |
| Exac | rs3024505 |
| Gnomad | rs3024505 |
| Varsome | rs3024505 |
| LitVar | rs3024505 |
| Map | rs3024505 |
| PheGenI | rs3024505 |
| Biobank | rs3024505 |
| 1000 genomes | rs3024505 |
| hgdp | rs3024505 |
| ensembl | rs3024505 |
| geneview | rs3024505 |
| scholar | rs3024505 |
| rs3024505 | |
| pharmgkb | rs3024505 |
| gwascentral | rs3024505 |
| openSNP | rs3024505 |
| 23andMe | rs3024505 |
| SNPshot | rs3024505 |
| SNPdbe | rs3024505 |
| MSV3d | rs3024505 |
| GWAS Ctlg | rs3024505 |
| GMAF | 0.09091 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 18836448] |
| Trait | Ulcerative colitis |
| Title | Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility |
| Risk Allele | T |
| P-val | 9.9999999999999998E-13 |
| Odds Ratio | 1.46 [1.31-1.62] |
| GWAS snp | |
|---|---|
| PMID | [PMID 19430480 ]
|
| Trait | Type 1 diabetes |
| Title | Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes |
| Risk Allele | |
| P-val | 2E-9 |
| Odds Ratio | 1.19 [1.10-1.30] |
| GWAS snp | |
|---|---|
| PMID | [PMID 20228799]
|
| Trait | Ulcerative colitis |
| Title | Genome-wide association identifies multiple ulcerative colitis susceptibility loci |
| Risk Allele | T |
| P-val | 1E-8 |
| Odds Ratio | 1.23 [NR] |
[PMID 20509889] The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
| GWAS snp | |
|---|---|
| PMID | [PMID 21102463]
|
| Trait | |
| Title | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci |
| Risk Allele | T |
| P-val | 2E-14 |
| Odds Ratio | 1.1200 [1.07-1.17] |
| GWAS snp | |
|---|---|
| PMID | [PMID 21297633]
|
| Trait | |
| Title | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 |
| Risk Allele | A |
| P-val | 6E-17 |
| Odds Ratio | 1.2500 [1.19-1.32] |
| GWAS snp | |
|---|---|
| PMID | [PMID 21829393]
|
| Trait | |
| Title | Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. |
| Risk Allele | G |
| P-val | 5E-10 |
| Odds Ratio | 1.2000 [NR] |
[PMID 22594912] Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study
[PMID 19468064] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.
[PMID 19698145] Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.
[PMID 19776214] SimCT: a generic tool to visualize ontology-based relationships for biological objects.
[PMID 19838195] A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
[PMID 20444268] Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.
[PMID 21245992] Polymorphisms in NF-kappaB, PXR, LXR, PPARgamma and risk of inflammatory bowel disease.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 21354456] The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.
[PMID 21379322] Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.
[PMID 21408207] Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
| GWAS snp | |
|---|---|
| PMID | [PMID 23128233]
|
| Trait | Inflammatory bowel disease |
| Title | Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. |
| Risk Allele | A |
| P-val | 7E-42 |
| Odds Ratio | 1.21 [1.163-1.254] |
[PMID 24130510] Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression
[PMID 24194923] Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study
[PMID 23348120] Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease.
[PMID 24971461] Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort
[PMID 26109419] Polymorphisms in ATP-binding cassette transporter genes and interaction with diet and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study
[PMID 27558476] The Polymorphism rs3024505 (C/T) Downstream of the IL10 Gene Is Associated with Crohn's Disease in Serbian Patients with Inflammatory Bowel Disease.
[PMID 29487192] Association of interleukin-10 gene single nucleotide polymorphisms with rheumatoid arthritis in a Chinese population.
[PMID 30882006] STAT4, TRAF3IP2, IL10, and HCP5 Polymorphisms in Sjögren's Syndrome: Association with Disease Susceptibility and Clinical Aspects.
[PMID 31651650] Genetic polymorphisms present in IL10, IL23R, NOD2, and ATG16L1 associated with susceptibility to inflammatory bowel disease in Mexican population.
