|(A;A)||3||5.2x risk for T1D; 3.3x for RA|
|(A;C)||2.3||1.8x risk for T1D; 2x risk for RA|
|?||(A;A) (A;C) (C;C)||28|
rs6679677 has been reported in a large study to be associated with rheumatoid arthritis.
The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.98 (CI 1.72-2.27), and for homozygotes, 3.32 (CI 1.93-5.69). [PMID 17554300]
rs6679677 was also reported in the same study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.82 (CI 1.59-2.09), and for homozygotes, 5.19 (CI 3.15-8.55). [PMID 17554300]
Recently (Feb 2008), it has been asserted that the association between rs6679677 and type-1 diabetes is actually completely due to a closely linked, potentially causal variant identified as rs2476601, which is also known as Arg620Trp. In this study, apparently the largest to date, the odds ratio for the risk allele (of rs6679677) was reported to be 1.88 (CI: 1.66-2.13).[PMID 18305142]
DeCode reports that the CC genotype is associated with 1.05x higher odds of Crohn's disease. [PMID 18587394]
|Trait||Type 1 diabetes|
|Title||Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci|
|Odds Ratio||NR NR|
|Title||Common variants at CD40 and other loci confer risk of rheumatoid arthritis|
|Odds Ratio||1.79 [1.65-1.94]|
|Trait||Type 1 diabetes|
|Title||Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes|
|Odds Ratio||1.89 [1.67-2.13]|
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|Title||Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.|
|Odds Ratio||1.20 [1.129-1.268]|
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