rs237025
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common in clinvar |
| (C;T) | 0 | |
| (T;T) | 0.5 | no credible risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 149400554 |
| Gene | SUMO4, TAB2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs237025 |
| dbSNP (classic) | rs237025 |
| ClinGen | rs237025 |
| ebi | rs237025 |
| HLI | rs237025 |
| Exac | rs237025 |
| Gnomad | rs237025 |
| Varsome | rs237025 |
| LitVar | rs237025 |
| Map | rs237025 |
| PheGenI | rs237025 |
| Biobank | rs237025 |
| 1000 genomes | rs237025 |
| hgdp | rs237025 |
| ensembl | rs237025 |
| geneview | rs237025 |
| scholar | rs237025 |
| rs237025 | |
| pharmgkb | rs237025 |
| gwascentral | rs237025 |
| openSNP | rs237025 |
| 23andMe | rs237025 |
| SNPshot | rs237025 |
| SNPdbe | rs237025 |
| MSV3d | rs237025 |
| GWAS Ctlg | rs237025 |
| GMAF | 0.3714 |
| Max Magnitude | 0.5 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 17374705] suggested the contribution of rs237025 to type-1 diabetes, however in [PMID 19956095
] this failed to replicate.
This SNP is also known as Met55Val, M55V, or A163G.
This was the first SNP in SNPedia.
| ClinVar | |
|---|---|
| Risk | Rs237025(T;T) |
| Alt | Rs237025(T;T) |
| Reference | Rs237025(C;C) |
| Significance | Other |
| Disease | Diabetes mellitus |
| Variation | info |
| Gene | TAB2 SUMO4 |
| CLNDBN | Diabetes mellitus, insulin-dependent, 5 |
| Reversed | 1 |
| HGVS | NC_000006.11:g.149721690G>A |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000002143.1, |
[PMID 16159953] The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis.
[PMID 16380915] Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
[PMID 16735488] Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.
[PMID 17229939] SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes.
[PMID 18330586] Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris.
[PMID 18466472] Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.
[PMID 18466513] Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.
[PMID 18466531] Case-control association analysis of rheumatoid arthritis with candidate genes using related cases.
[PMID 18466554] Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests.
[PMID 18466563] Classification of rheumatoid arthritis status with candidate gene and genome-wide single-nucleotide polymorphisms using random forests.
[PMID 18560894] Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population.
[PMID 19122825] Small ubiquitin-like modifier 4 (SUMO4) polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome in the Chinese Han population.
[PMID 19956101] Overview of the Rapid Response data.
[PMID 19956109] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.
[PMID 23042402] [Association between SUMO4 polymorphisms and coronary artery disease with and without type 2 diabetes mellitus]
[PMID 25901130] Genetic polymorphisms of NFκB1 -94 del/ins ATTG, NFκB1A 2758 A>G and SUMO rs237025 G>A in psoriasis
[PMID 27899942] Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes.
