rs174575
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | |
| (C;G) | ||
| (G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 61834531 |
| Gene | FADS2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs174575 |
| dbSNP (classic) | rs174575 |
| ClinGen | rs174575 |
| ebi | rs174575 |
| HLI | rs174575 |
| Exac | rs174575 |
| Gnomad | rs174575 |
| Varsome | rs174575 |
| LitVar | rs174575 |
| Map | rs174575 |
| PheGenI | rs174575 |
| Biobank | rs174575 |
| 1000 genomes | rs174575 |
| hgdp | rs174575 |
| ensembl | rs174575 |
| geneview | rs174575 |
| scholar | rs174575 |
| rs174575 | |
| pharmgkb | rs174575 |
| gwascentral | rs174575 |
| openSNP | rs174575 |
| 23andMe | rs174575 |
| SNPshot | rs174575 |
| SNPdbe | rs174575 |
| MSV3d | rs174575 |
| GWAS Ctlg | rs174575 |
| GMAF | 0.2328 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs174575, has been investigated with respect to increased intelligence in breastfed children but not yielded any clear result.
- Although there was no difference in IQ linked to the SNP alone, breastfed children carrying one or two copies of rs174575(C) had a significant (6 point) increase in IQ compared to carriers of the same allele who were not breastfed. For children who were homozygous non-carriers, i.e. rs174575(G;G) individuals, there was no effect of breastfeeding on IQ. [PMID 17984066
] - did not replicate those findings. In contrast to their study, (G;G) children exhibited the greatest difference between feeding methods such that breastfed children performed similarly irrespective of child genotype whereas formula fed (G;G) children performed worse than other children on formula milk [PMID 20644632]
Expanded discussion at http://eurogene.blogspot.com/2011/06/genetic-testing-and-potential-harm-dtc.html
[PMID 20335541] FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk
[PMID 20395685] Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study
[PMID 18936223] Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation.
[PMID 20565855
] Genetic variation in lipid desaturases and its impact on the development of human disease.
[PMID 21040914] FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease.
[PMID 21156270] Cognitive function in adolescence: testing for interactions between breast-feeding and FADS2 polymorphisms.
[PMID 21793953] FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children.
[PMID 22194195] Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms.
[PMID 23636240] FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants.
[PMID 23737301] A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems.
[PMID 26455892] Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance
[PMID 32127356] Risk SNP-mediated enhancer-promoter interaction drives colorectal cancer through both FADS2 and AP002754.2.
