rs17465637

plus

Geno	Mag	Summary
(A;A)	0
(A;C)	1.17	1.17x higher risk for myocardial infarction
(C;C)	1.34	1.34x higher risk for myocardial infarction

Reference

GRCh38 38.1/141

Chromosome

1

Position

222650187

Gene

MIA3

is a	snp
is	mentioned by
dbSNP	rs17465637
dbSNP (classic)	rs17465637
ClinGen	rs17465637
ebi	rs17465637
HLI	rs17465637
Exac	rs17465637
Gnomad	rs17465637
Varsome	rs17465637
LitVar	rs17465637
Map	rs17465637
PheGenI	rs17465637
Biobank	rs17465637
1000 genomes	rs17465637
hgdp	rs17465637
ensembl	rs17465637
geneview	rs17465637
scholar	rs17465637
google	rs17465637
pharmgkb	rs17465637
gwascentral	rs17465637
openSNP	rs17465637
23andMe	rs17465637
SNPshot	rs17465637
SNPdbe	rs17465637
MSV3d	rs17465637
GWAS Ctlg	rs17465637

GMAF

0.4518

Max Magnitude

1.34

?

(A;A) (A;C) (C;C)

28

rs17465637 is a SNP found to be associated with heart disease by the German MI (Myocardial infarction) Family Study group [PMID 17634449 ]

[PMID 21264445] This 2011 study concluded that the only MIA3 gene SNP to be associated with increased risk for myocardial infarction is rs17465637, with an odds ratio of 1.17 (CI: 1.04-1.32) and 1.37 (CI: 1.08-1.74) for carriers of one or two (C) alleles, respectively.

23andMe blog coronary artery disease and heart attack

SNP Risk Version Effect

rs646776 T 1.19
rs17465637 C 1.14
rs1746048 C 1.17
rs6725887 C 1.17
rs11206510 T 1.15
rs3184504 T 1.13
rs2306374 C 1.15
rs3782886 C 1.44

GWAS snp
PMID	[PMID 19198609 ]
Trait	Myocardial infarction (early onset)
Title	Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
Risk Allele	C
P-val	1E-9
Odds Ratio	1.14 [1.10-1.19]

[PMID 21463265 ] Association of SNP rs17465637 on Chromosome 1q41 and rs599839 on 1p13.3 with Myocardial Infarction in an American Caucasian Population

GWAS snp
PMID	[PMID 21378990 ]
Trait
Title	Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Risk Allele	C
P-val	1E-8
Odds Ratio	1.1400 [1.09-1.20]

[PMID 22856164] [Evaluation of association between 9 genetic polymorphism and myocardial infarction in the Siberian population]

[PMID 18654002] Validation of the association of genetic variants on chromosome 9p21 and 1q41 with myocardial infarction in a Japanese population.

[PMID 18979498 ] The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.

[PMID 19750184 ] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

[PMID 19956433 ] Genetics of coronary artery disease: focus on genome-wide association studies.

[PMID 20017983 ] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.

[PMID 20098575 ] Genetics and cardiovascular disease: Design and development of a DNA biobank.

[PMID 20835900 ] Genetics of diabetes complications.

[PMID 21804106 ] Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

[PMID 21984477] Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in established coronary artery disease.

[PMID 22577832] Association Study of MIA3 rs17465637 Polymorphism with Cardiovascular Disease in Rheumatoid Arthritis Patients.

[PMID 24125424] Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease

[PMID 31804579 ] The Mediterranean diet reduces the genetic risk of chromosome 9p21 for myocardial infarction in an Asian population community cohort.