rs17482753

plus

Geno	Mag	Summary
(G;G)	0	normal
(G;T)		elevated triglycerides
(T;T)		elevated triglycerides

Reference

GRCh38 38.1/141

Chromosome

8

Position

19975135

is a	snp
is	mentioned by
dbSNP	rs17482753
dbSNP (classic)	rs17482753
ClinGen	rs17482753
ebi	rs17482753
HLI	rs17482753
Exac	rs17482753
Gnomad	rs17482753
Varsome	rs17482753
LitVar	rs17482753
Map	rs17482753
PheGenI	rs17482753
Biobank	rs17482753
1000 genomes	rs17482753
hgdp	rs17482753
ensembl	rs17482753
geneview	rs17482753
scholar	rs17482753
google	rs17482753
pharmgkb	rs17482753
gwascentral	rs17482753
openSNP	rs17482753
23andMe	rs17482753
SNPshot	rs17482753
SNPdbe	rs17482753
MSV3d	rs17482753
GWAS Ctlg	rs17482753

GMAF

0.09412

Max Magnitude

0

?

(G;G) (G;T) (T;T)

28

Rs17482753
PubMed	[PMID 17463246]
Affy Probeset	SNP_A-2105269
Affy Orientation	same
On GW 5.0	1
Alleles A/B	G/T
Ancestral	G
Population	NEU
Allele	T
Case Freq.
Control Freq.	0.1
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All	-
Disease	Elevated HDL-Cholesterol (E-HDL)

rs17482753 increases susceptibility to Elevated HDL-Cholesterol for carriers of the T allele [PMID 17463246]

rs17482753 increases susceptibility to Elevated triglycerides for carriers of the T allele [PMID 17463246]

GWAS snp
PMID	[PMID 20031538]
Trait	HDL cholesterol
Title	Genome-Wide Association Analysis of High-Density Lipoprotein Cholesterol in the Population-Based KORA Study Sheds New Light on Intergenic Regions
Risk Allele	T
P-val	3E-11
Odds Ratio	2.02 [NR] mg/dl increase

[PMID 18179892 ] Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

[PMID 19041386 ] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

[PMID 19148283 ] Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.

[PMID 19161620 ] An open access database of genome-wide association results.

[PMID 19656773 ] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

[PMID 20018038 ] Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study.

[PMID 20018072 ] Different models and single-nucleotide polymorphisms signal the simulated weak gene-gene interaction for a quantitative trait using haplotype-based and mixed models testing.

[PMID 20370913 ] Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.

GWAS snp
PMID	[PMID 24023261 ]
Trait	Lipid traits
Title	THOC5: a novel gene involved in HDL-cholesterol metabolism.
Risk Allele	T
P-val	6E-10
Odds Ratio	-.24 unit decrease