rs17487223
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | normal | |
| (C;T) | 2 | Higher lung cancer risk? |
| (T;T) | 2.5 | 1.28x lung cancer risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 15 |
| Position | 78631645 |
| Gene | CHRNB4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs17487223 |
| dbSNP (classic) | rs17487223 |
| ClinGen | rs17487223 |
| ebi | rs17487223 |
| HLI | rs17487223 |
| Exac | rs17487223 |
| Gnomad | rs17487223 |
| Varsome | rs17487223 |
| LitVar | rs17487223 |
| Map | rs17487223 |
| PheGenI | rs17487223 |
| Biobank | rs17487223 |
| 1000 genomes | rs17487223 |
| hgdp | rs17487223 |
| ensembl | rs17487223 |
| geneview | rs17487223 |
| scholar | rs17487223 |
| rs17487223 | |
| pharmgkb | rs17487223 |
| gwascentral | rs17487223 |
| openSNP | rs17487223 |
| 23andMe | rs17487223 |
| SNPshot | rs17487223 |
| SNPdbe | rs17487223 |
| MSV3d | rs17487223 |
| GWAS Ctlg | rs17487223 |
| GMAF | 0.2094 |
| Max Magnitude | 2.5 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
| Rs17487223 | |
|---|---|
| PubMed | [PMID 18385738] |
| Affy Probeset | SNP_A-8440085 |
| Affy Orientation | reverse |
| On GW 5.0 | |
| Alleles A/B | A/G |
| Ancestral | |
| Population | Caucasian(Europe) |
| Allele | T |
| Case Freq. | 0.42 |
| Control Freq. | 0.36 |
| Odds Ratio Het | |
| Odds Ratio Hom | |
| Odds Ratio All | 1.28 |
| Disease | Lung cancer (LC) |
rs17487223 increases susceptibility to Lung cancer 1.28 times for carriers of the T allele [PMID 18385738]
plos Risk Factors for Age-Dependent Nicotine Addiction
[PMID 18519524
] Variants in nicotinic receptors and risk for nicotine dependence.
[PMID 18618000] A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.
[PMID 18759969] In search of causal variants: refining disease association signals using cross-population contrasts.
[PMID 19029397] Nicotinic receptor gene variants influence susceptibility to heavy smoking.
[PMID 19259974] Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
[PMID 19330903] Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.
[PMID 19443489] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
[PMID 19706762] The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
[PMID 29666375] Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population.
