rs17611

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(G;G)	0	common in clinvar

Make rs17611(A;A)

Make rs17611(A;G)

Reference

GRCh38 38.1/141

Chromosome

9

Position

121006922

Gene

C5

is a	snp
is	mentioned by
dbSNP	rs17611
dbSNP (classic)	rs17611
ClinGen	rs17611
ebi	rs17611
HLI	rs17611
Exac	rs17611
Gnomad	rs17611
Varsome	rs17611
LitVar	rs17611
Map	rs17611
PheGenI	rs17611
Biobank	rs17611
1000 genomes	rs17611
hgdp	rs17611
ensembl	rs17611
geneview	rs17611
scholar	rs17611
google	rs17611
pharmgkb	rs17611
gwascentral	rs17611
openSNP	rs17611
23andMe	rs17611
SNPshot	rs17611
SNPdbe	rs17611
MSV3d	rs17611
GWAS Ctlg	rs17611

GMAF

0.4073

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

[PMID 19028820] Although rs17611 was the only SNP to remain significant after multivariate analysis (odds ratio 0.585, p = 0.0037) in a study of 459 patients, ROC curve analysis did not show any contribution of this SNP to overall stroke risk.

OMIM	120900
Desc	COMPLEMENT COMPONENT 5; C5
Variant
Related	also

[PMID 19619703] Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study

[PMID 19909405] Single nucleotide polymorphisms of complement component 5 and periodontitis

OMIM	120900
Desc
Variant	0005
Related	also

[PMID 21871809] Complement Factor H Y402H polymorphism is associated with an increased risk of mortality after intracerebral hemorrhage

[PMID 22452399] Polymorphism of the complement 5 gene and cardiovascular outcome in patients with atherosclerosis

[PMID 15371359] Testing for Hardy-Weinberg equilibrium in samples with related individuals.

[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 17428459] Gc-globulin concentrations and C5 haplotype-tagging polymorphisms contribute to variations in serum activity of complement factor C5.

[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18644651] Evaluation of complement factor 5 variants as genetic risk factors for the development of advanced fibrosis in chronic hepatitis C infection.

[PMID 18648537] A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.

[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 20018035] A combinatorial approach for detecting gene-gene interaction using multiple traits of Genetic Analysis Workshop 16 rheumatoid arthritis data.

[PMID 21393613] Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea.

[PMID 23662819] Complement polymorphisms and cognitive dysfunction after carotid endarterectomy.

[PMID 25725109] Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis

[PMID 26092810] Response to Comment on "Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis"

[PMID 26092809] Comment on "Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis"

ClinVar
Risk	rs17611(A;A)
Alt	rs17611(A;A)
Reference	Rs17611(G;G)
Significance	Non-pathogenic
Disease	not specified
Variation	info
Gene	C5
CLNDBN	not specified
Reversed	1
HGVS	NC_000009.11:g.123769200C>T
CLNSRC
CLNACC	RCV000454843.1,

[PMID 31570557] Association of TRAF1/C5 locus polymorphisms with epilepsy and clinical traits in Mexican neurocysticercosis patients.