rs1799883
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | Two copies of the Thr allele in the FABP2 is associated with significantly increased sensitivity to saturated fats. Also contributes to increased refined carb sensitivity. |
| (A;G) | A single copy of the Thr allele associated with a moderately increased sensitivity to saturated fats. Also contributes to increased refined carb sensitivity. | |
| (G;G) | This genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates. |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 119320747 |
| Gene | FABP2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1799883 |
| dbSNP (classic) | rs1799883 |
| ClinGen | rs1799883 |
| ebi | rs1799883 |
| HLI | rs1799883 |
| Exac | rs1799883 |
| Gnomad | rs1799883 |
| Varsome | rs1799883 |
| LitVar | rs1799883 |
| Map | rs1799883 |
| PheGenI | rs1799883 |
| Biobank | rs1799883 |
| 1000 genomes | rs1799883 |
| hgdp | rs1799883 |
| ensembl | rs1799883 |
| geneview | rs1799883 |
| scholar | rs1799883 |
| rs1799883 | |
| pharmgkb | rs1799883 |
| gwascentral | rs1799883 |
| openSNP | rs1799883 |
| 23andMe | rs1799883 |
| SNPshot | rs1799883 |
| SNPdbe | rs1799883 |
| MSV3d | rs1799883 |
| GWAS Ctlg | rs1799883 |
| GMAF | 0.2521 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs1799883 Fatty acid binding protein 2 (FABP2) Ala54Thr;
The derived allele at SNP (A54T), rs1799883, in FABP2 increases strongly with latitude (p < 0.01) [PMID 18282109
]
and may influence weight management
| ClinVar | |
|---|---|
| Risk | rs1799883(C;C) Rs1799883(G;G) rs1799883(T;T) |
| Alt | rs1799883(C;C) Rs1799883(G;G) rs1799883(T;T) |
| Reference | Rs1799883(A;A) |
| Significance | Non-pathogenic |
| Disease | FATTY ACID-BINDING PROTEIN |
| Variation | info |
| Gene | FABP2 |
| CLNDBN | FATTY ACID-BINDING PROTEIN, INTESTINAL, POLYMORPHISM OF |
| Reversed | 1 |
| HGVS | NC_000004.11:g.120241902T>C |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000017958.2, |
[PMID 16175505] Identification of four gene variants associated with myocardial infarction.
[PMID 18506375] Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome.
[PMID 19288030] Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus.
[PMID 19379518] Development of a fingerprinting panel using medically relevant polymorphisms.
[PMID 20413122] Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial.
[PMID 20416077] Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
[PMID 23826253] Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study
[PMID 22038464] Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content.
