rs1799929

plus

Geno	Mag	Summary
(C;C)	0

Make rs1799929(C;T)

Make rs1799929(T;T)

Reference

GRCh38 38.1/141

Chromosome

8

Position

18400484

Gene

NAT2

is a	snp
is	mentioned by
dbSNP	rs1799929
dbSNP (classic)	rs1799929
ClinGen	rs1799929
ebi	rs1799929
HLI	rs1799929
Exac	rs1799929
Gnomad	rs1799929
Varsome	rs1799929
LitVar	rs1799929
Map	rs1799929
PheGenI	rs1799929
Biobank	rs1799929
1000 genomes	rs1799929
hgdp	rs1799929
ensembl	rs1799929
geneview	rs1799929
scholar	rs1799929
google	rs1799929
pharmgkb	rs1799929
gwascentral	rs1799929
openSNP	rs1799929
23andMe	rs1799929
SNPshot	rs1799929
SNPdbe	rs1799929
MSV3d	rs1799929
GWAS Ctlg	rs1799929

GMAF

0.2773

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

rs1799929 is a SNP in the NAT2 gene, potentially encoding a variant detoxifying protein known as an N-acetyltransferase, but which NAT2 variant depends on which other NAT2 SNPs were also inherited. See the discussion of the NAT2 gene for a more complete explanation.

The risk allele for this SNP is rs1799929(T).

When this SNP is indicative of carrying a NAT2*5A allele, the following may be relevant:

A study (based on only 42 patients) found that women with the NAT2*5A slow genotype (which presumably means rs1799929(T;T)) had a significantly higher risk of cervical cancer compared with individuals with the NAT2*5A fast genotype (i.e. carriers of only one rs1799929(T) allele), with a reported odds ratio of 7.469 (CI: 1.6-33.3, p=0.008).[PMID 19823052]

[PMID 22092036 ] Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes

[PMID 14724163 ] Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.

[PMID 16112301 ] NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.

[PMID 16416399 ] Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.

[PMID 16847422 ] Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma.

[PMID 17160896 ] Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.

[PMID 17335581 ] Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus.

[PMID 18547414 ] Genotyping panel for assessing response to cancer chemotherapy.

[PMID 18664443] Unraveling ambiguous NAT2 genotyping data.

[PMID 18680467 ] Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.

[PMID 18773084 ] Multiple advantageous amino acid variants in the NAT2 gene in human populations.

[PMID 19766908] Association of NAT2 gene polymorphisms with susceptibility to esophageal and gastric cancers in the Kashmir Valley.

[PMID 20043821 ] Evaluating NAT2PRED for inferring the individual acetylation status from unphased genotype data.

[PMID 22137356] An unlikely role for the NAT2 genotypes and haplotypes in the oral cancer of south Indians.

[PMID 24928356] Synergism between the N-acetyltransferase 2 gene and oxidant exposure increases the risk of idiopathic male infertility

[PMID 25017831] N-acetyltransferase and cytochrome P450 2E1 gene polymorphisms and susceptibility to antituberculosis drug hepatotoxicity in an Indian population

[PMID 26409796 ] N-acetyltransferase 1 and 2 polymorphisms and risk of diabetes mellitus type 2 in a Saudi population

[PMID 26445549 ] Associations of polymorphisms in NAT2 gene with risk and metastasis of osteosarcoma in young Chinese population

[PMID 29505746] Association of N-acetyltransferase-2 and glutathione S-transferase polymorphisms with idiopathic male infertility in Vietnam male subjects.