||greater relative benefit of iloperidone to schizophrenics
rs1800169 is a SNP in the ciliary neurotrophic factor CNTF gene.
In a study of 417 patients with schizophrenia, 279 were treated with iloperidone while 138 were treated with placebo. Iloperidone significantly improved in 6 clinical scores versus placebo. rs1800169(G;G) homozygotes showed greater improvement with iloperidone compared to placebo for 3 of the clinical scores compared to carriers of a rs1800169(A) allele.[PMID 18303965]
[PMID 19833146] Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain
[PMID 16696750] Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women.
[PMID 20368905] New atypical antipsychotics for schizophrenia: iloperidone.