rs1801275
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 |
| Make rs1801275(A;G) |
| Make rs1801275(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 16 |
| Position | 27363079 |
| Gene | IL4R |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1801275 |
| dbSNP (classic) | rs1801275 |
| ClinGen | rs1801275 |
| ebi | rs1801275 |
| HLI | rs1801275 |
| Exac | rs1801275 |
| Gnomad | rs1801275 |
| Varsome | rs1801275 |
| LitVar | rs1801275 |
| Map | rs1801275 |
| PheGenI | rs1801275 |
| Biobank | rs1801275 |
| 1000 genomes | rs1801275 |
| hgdp | rs1801275 |
| ensembl | rs1801275 |
| geneview | rs1801275 |
| scholar | rs1801275 |
| rs1801275 | |
| pharmgkb | rs1801275 |
| gwascentral | rs1801275 |
| openSNP | rs1801275 |
| 23andMe | rs1801275 |
| SNPshot | rs1801275 |
| SNPdbe | rs1801275 |
| MSV3d | rs1801275 |
| GWAS Ctlg | rs1801275 |
| GMAF | 0.3453 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 19515749] Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial
[PMID 19956098
] Association analysis of SNPs in the IL4R locus with type I diabetes
[PMID 21196282] Single nucleotide polymorphisms in IL-4Ra, IL-13 and STAT6 genes occurs in brain glioma
[PMID 21734400] Attempted Replication of 50 Reported Asthma Risk Genes Identifies a SNP in RAD50 as Associated with Childhood Atopic Asthma
[PMID 22119518] Interleukin-4 receptor alpha polymorphisms in autoimmune myasthenia gravis in a Caucasian population
| GWAS snp | |
|---|---|
| PMID | [PMID 22075330]
|
| Trait | |
| Title | A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. |
| Risk Allele | G |
| P-val | 1E-7 |
| Odds Ratio | 0.0500 None |
| ClinVar | |
|---|---|
| Risk | rs1801275(G;G) |
| Alt | rs1801275(G;G) |
| Reference | Rs1801275(A;A) |
| Significance | Other |
| Disease | Atopy |
| Variation | info |
| Gene | IL4R |
| CLNDBN | Atopy, susceptibility to |
| Reversed | 0 |
| HGVS | NC_000016.9:g.27374400A>G |
| CLNSRC | OMIM Allelic Variant UniProtKB (protein) |
| CLNACC | RCV000015775.3, |
[PMID 15660293] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.
[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 16024651] Polymorphisms associated with asthma are inversely related to glioblastoma multiforme.
[PMID 16759385] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).
[PMID 16842617] Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.
[PMID 17083349] Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study.
[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
[PMID 17940599] Assembly of inflammation-related genes for pathway-focused genetic analysis.
[PMID 18006935] An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk.
[PMID 18625055] Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.
[PMID 18781131] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.
[PMID 18936436] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.
[PMID 19956101] Overview of the Rapid Response data.
[PMID 19956109] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.
[PMID 20298583] Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.
[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
[PMID 22045834] Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.
[PMID 22369735] Polymorphisms of TREH, IL4R and CCDC26 genes associated with risk of glioma.
[PMID 23480403] Case-control study of eczema in relation to IL4Rα genetic polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study
[PMID 23299779] Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma
[PMID 23924473] Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma
[PMID 23979976] Association of the interleukin-4Rα rs1801275 and rs1805015 polymorphisms with glioma risk
[PMID 23996684] Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry
[PMID 22902050] Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma.
[PMID 23395224] Association between polymorphisms in interleukin-4Ralpha and interleukin-13 and glioma risk: a meta-analysis.
[PMID 25110223] rs1801275 Interleukin-4 receptor alpha polymorphism in familial hypercholesterolemia
[PMID 25785117] Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis
[PMID 26391153] Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal
[PMID 28289589] Polymorphism of the IL13 gene may be associated with Uterine leiomyomas in Slovenian women.
[PMID 30227113] Association study on IL-4, IL-4Rα and IL-13 genetic polymorphisms in Swedish patients with colorectal cancer.
[PMID 31264107] Association between interleukin-4 and interleukin-10 single nucleotide polymorphisms and multiple sclerosis among Iraqi patients.
