rs1805015

Orientation

plus

Stabilized

plus

Make rs1805015(C;C)

Make rs1805015(C;T)

Make rs1805015(T;T)

Reference

GRCh38 38.1/141

Chromosome

16

Position

27362859

Gene

IL4R

is a	snp
is	mentioned by
dbSNP	rs1805015
dbSNP (classic)	rs1805015
ClinGen	rs1805015
ebi	rs1805015
HLI	rs1805015
Exac	rs1805015
Gnomad	rs1805015
Varsome	rs1805015
LitVar	rs1805015
Map	rs1805015
PheGenI	rs1805015
Biobank	rs1805015
1000 genomes	rs1805015
hgdp	rs1805015
ensembl	rs1805015
geneview	rs1805015
scholar	rs1805015
google	rs1805015
pharmgkb	rs1805015
gwascentral	rs1805015
openSNP	rs1805015
23andMe	rs1805015
SNPshot	rs1805015
SNPdbe	rs1805015
MSV3d	rs1805015
GWAS Ctlg	rs1805015

Merged from

0.2098

0

(C;C) (C;T) (T;T)

28

[PMID 18927306 ] among high-grade glioma cases rs1805016 (TT versus GT/GG) was significantly protective against mortality over time [hazard ratios (HR), 0.59; 95% confidence intervals (CI), 0.40-0.88]. The IL4R rs1805016 and rs1805015 TT genotypes were both found to be significantly associated with survival beyond 1 year among patients with high-grade glioma (HR, 0.44; 95% CI, 0.27-0.73 and HR, 0.63; 95% CI, 0.44-0.91, respectively)

[PMID 19515749] Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial

OMIM	147781
Desc
Variant	0003
Related	also

[PMID 22119518] Interleukin-4 receptor alpha polymorphisms in autoimmune myasthenia gravis in a Caucasian population

[PMID 21867552 ] Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites

ClinVar
Risk	rs1805015(C;C)
Alt	rs1805015(C;C)
Reference	rs1805015(T;T)
Significance	Other
Disease	Atopy
Variation	info
Gene	IL4R
CLNDBN	Atopy, resistance to
Reversed	0
HGVS	NC_000016.9:g.27374180T>C
CLNSRC	OMIM Allelic Variant UniProtKB (protein)
CLNACC	RCV000015778.25,

[PMID 15660293 ] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.

[PMID 15726497 ] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16024651 ] Polymorphisms associated with asthma are inversely related to glioblastoma multiforme.

[PMID 16600026 ] Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.

[PMID 17303794 ] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.

[PMID 17705862 ] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18006935] An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk.

[PMID 18256354 ] IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy.

[PMID 18936436 ] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

[PMID 19131662 ] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19263529 ] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19264973 ] Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

[PMID 19330901 ] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19356949 ] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19559392 ] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19956098 ] Association analysis of SNPs in the IL4R locus with type I diabetes.

[PMID 19956101 ] Overview of the Rapid Response data.

[PMID 19956109 ] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

[PMID 20219689] Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis.

[PMID 20298583 ] Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.

[PMID 20401335 ] Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.

[PMID 20459687 ] Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.

[PMID 20811626 ] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 21111021] Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.

[PMID 23480403] Case-control study of eczema in relation to IL4Rα genetic polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

[PMID 23924473] Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma

[PMID 23979976] Association of the interleukin-4Rα rs1801275 and rs1805015 polymorphisms with glioma risk

[PMID 22902050 ] Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma.

[PMID 23462527] IL4R and IL13 polymorphic variants and development of antibodies to surface antigen of hepatitis B virus in hemodialysis patients in response to HBV vaccination or infection.

[PMID 23663310 ] Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.

[PMID 25785117 ] Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis

[PMID 26448013 ] High Incidence of Malaria Along the Sino-Burmese Border Is Associated With Polymorphisms of CR1, IL-1A, IL-4R, IL-4, NOS, and TNF, But Not With G6PD Deficiency