rs1805096
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common in clinvar |
| Make rs1805096(C;T) |
| Make rs1805096(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 65636574 |
| Gene | LEPR |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1805096 |
| dbSNP (classic) | rs1805096 |
| ClinGen | rs1805096 |
| ebi | rs1805096 |
| HLI | rs1805096 |
| Exac | rs1805096 |
| Gnomad | rs1805096 |
| Varsome | rs1805096 |
| LitVar | rs1805096 |
| Map | rs1805096 |
| PheGenI | rs1805096 |
| Biobank | rs1805096 |
| 1000 genomes | rs1805096 |
| hgdp | rs1805096 |
| ensembl | rs1805096 |
| geneview | rs1805096 |
| scholar | rs1805096 |
| rs1805096 | |
| pharmgkb | rs1805096 |
| gwascentral | rs1805096 |
| openSNP | rs1805096 |
| 23andMe | rs1805096 |
| SNPshot | rs1805096 |
| SNPdbe | rs1805096 |
| MSV3d | rs1805096 |
| GWAS Ctlg | rs1805096 |
| GMAF | 0.4587 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 20032477] Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults
[PMID 15113403
] Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.
[PMID 15157284] Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes.
[PMID 16580675] Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels.
[PMID 18212354] Genes in glucose metabolism and association with spina bifida.
[PMID 18700015] Linkage study of fibrinogen levels: the Strong Heart Family Study.
[PMID 19401628] Host genetics, steatosis and insulin resistance among African Americans and Caucasian Americans with hepatitis C virus genotype-1 infection.
[PMID 19584180] Association between C-reactive protein and adiposity in women.
[PMID 20616999] Usefulness of Mendelian randomization in observational epidemiology.
| GWAS snp | |
|---|---|
| PMID | [PMID 22939635]
|
| Trait | C-reactive protein |
| Title | Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. |
| Risk Allele | A |
| P-val | 2E-9 |
| Odds Ratio | .11 [0.064-0.162] unit decrease |
[PMID 22975643] Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training.
| ClinVar | |
|---|---|
| Risk | rs1805096(T;T) |
| Alt | rs1805096(T;T) |
| Reference | Rs1805096(C;C) |
| Significance | Non-pathogenic |
| Disease | Leptin receptor deficiency Monogenic Non-Syndromic Obesity |
| Variation | info |
| Gene | LEPR LEPROT |
| CLNDBN | Leptin receptor deficiency Monogenic Non-Syndromic Obesity |
| Reversed | 1 |
| HGVS | NC_000001.10:g.66102257G>A |
| CLNSRC | |
| CLNACC | RCV000280669.1, RCV000335664.1, |
[PMID 31038568] Adipokine gene variability and plasma levels in patients with chronic periodontitis -a case-control study.
