rs1805097
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | twice as likely to reach extreme old age? | |
| (A;G) | normal | |
| (G;G) | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 13 |
| Position | 109782884 |
| Gene | IRS2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1805097 |
| dbSNP (classic) | rs1805097 |
| ClinGen | rs1805097 |
| ebi | rs1805097 |
| HLI | rs1805097 |
| Exac | rs1805097 |
| Gnomad | rs1805097 |
| Varsome | rs1805097 |
| LitVar | rs1805097 |
| Map | rs1805097 |
| PheGenI | rs1805097 |
| Biobank | rs1805097 |
| 1000 genomes | rs1805097 |
| hgdp | rs1805097 |
| ensembl | rs1805097 |
| geneview | rs1805097 |
| scholar | rs1805097 |
| rs1805097 | |
| pharmgkb | rs1805097 |
| gwascentral | rs1805097 |
| openSNP | rs1805097 |
| 23andMe | rs1805097 |
| SNPshot | rs1805097 |
| SNPdbe | rs1805097 |
| MSV3d | rs1805097 |
| GWAS Ctlg | rs1805097 |
| GMAF | 0.2971 |
| Max Magnitude | 0 |
rs1805097, also known as Gly1057Asp, is a SNP in the insulin receptor substrate-2 IRS2 gene. The rs1805097(G) allele is associated with the Gly, and the (A) allele with Asp.
A longevity study categorizing 677 participants as either long-lived (i.e. over 85 years old) or not (less than 85) somehow concluded that rs1805097(A;A) individuals were about twice as likely to reach extreme old age (odds ratio 2.03, CI:1.39-2.99, p = .0003).[PMID 19887537]
[PMID 19818665] Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm
| ClinVar | |
|---|---|
| Risk | Rs1805097(A;A) |
| Alt | Rs1805097(A;A) |
| Reference | Rs1805097(G;G) |
| Significance | Other |
| Disease | DIABETES |
| Variation | info |
| Gene | IRS2 |
| CLNDBN | DIABETES, TYPE II, SUSCEPTIBILITY TO |
| Reversed | 1 |
| HGVS | NC_000013.10:g.110435231C>T |
| CLNSRC | OMIM Allelic Variant UniProtKB (protein) |
| CLNACC | RCV000009368.3, |
[PMID 18398040
] Transcription factor 7-like 2 polymorphism and colon cancer.
[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
[PMID 18611262] Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.
[PMID 18992263] Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.
[PMID 19124510] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.
