rs1835740

minus

Geno	Mag	Summary
(A;A)	1	higher risk for migraine in 1 study which has not replicated
(A;G)	1	unreplicated, higher risk for migraine
(G;G)	0	normal

Reference

GRCh38 38.1/141

Chromosome

8

Position

97154685

Gene	LOC101927066, LOC105375655

is a	snp
is	mentioned by
dbSNP	rs1835740
dbSNP (classic)	rs1835740
ClinGen	rs1835740
ebi	rs1835740
HLI	rs1835740
Exac	rs1835740
Gnomad	rs1835740
Varsome	rs1835740
LitVar	rs1835740
Map	rs1835740
PheGenI	rs1835740
Biobank	rs1835740
1000 genomes	rs1835740
hgdp	rs1835740
ensembl	rs1835740
geneview	rs1835740
scholar	rs1835740
google	rs1835740
pharmgkb	rs1835740
gwascentral	rs1835740
openSNP	rs1835740
23andMe	rs1835740
SNPshot	rs1835740
SNPdbe	rs1835740
MSV3d	rs1835740
GWAS Ctlg	rs1835740

GMAF

0.3343

Max Magnitude

1

?

(A;A) (A;G) (G;G)

28

rs1835740 is a SNP from the 8q22.1 chromosomal region, best known for harboring various genes involved in glutamate metabolism and transport.

A large study comprising over 5,000 migraine patients and over 10,000 matched controls, primarily from Europe, found that the rs1835740(A) allele conferred a (slightly) higher risk for the disorder. The reported odds ratio was 1.18, (CI: 1.127–1.244, p = 1.69 × 10e-11).[PMID 20802479 ]. However this study has failed to replicate in 2 followups.

[PMID 22072275 ] Genetics of migraine in the age of genome-wide association studies

[PMID 22103325] A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura

[PMID 21964821 ] Genotype-phenotype correlation in migraine without aura focusing on the rs1835740 variant on 8q22.1.

[PMID 22908361] A replication study of a GWAS finding in migraine does not identify association in a Spanish case-control sample.

[PMID 24674449 ] A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample

[PMID 30382894 ] Implications for the migraine SNP rs1835740 in a Swedish cluster headache population.