| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
normal/common in clinvar
|
| (C;T)
|
2.2
|
reduced risk (0.84x) for late-onset (adult) asthma
|
| (T;T)
|
2.8
|
reduced risk (0.73) for late-onset (adult) asthma
|
|
|
rs1837253 is a SNP found a bit upstream of the thymic stromal lymphopoietin TSLP gene on chromosome 5. The TSLP protein plays a role in inflammation of cells in the trachea and alveoli therefore may have a causative role in certain types of asthma.
The rs1837253(T) allele has been found to reduce the risk of developing late-onset (adult) asthma in several studies, and it is recognized by the CPMC Study as one they report to their participants.
| GWAS snp
|
| PMID
|
[PMID 21804548 ]
|
| Trait
|
|
| Title
|
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
|
| Risk Allele
|
C
|
| P-val
|
1E-16
|
| Odds Ratio
|
1.1700 [1.13-1.22]
|
| GWAS snp
|
| PMID
|
[PMID 21804549]
|
| Trait
|
|
| Title
|
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
| Risk Allele
|
|
| P-val
|
1E-14
|
| Odds Ratio
|
None None
|
[PMID 19539984] A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness.
[PMID 20560908] TSLP polymorphisms are associated with asthma in a sex-specific fashion.
[PMID 21244681] Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma.
| GWAS snp
|
| PMID
|
[PMID 24388013]
|
| Trait
|
Asthma and hay fever
|
| Title
|
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
| Risk Allele
|
C
|
| P-val
|
1E-9
|
| Odds Ratio
|
1.17 [1.12-1.24]
|
[PMID 25700684] Association Between TSLP Polymorphisms and Eczema in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study
]
