rs1859345
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | slightly earlier age at menarche | |
| (C;T) | normal | |
| (T;T) | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 137111731 |
| Gene | SPOCK1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1859345 |
| dbSNP (classic) | rs1859345 |
| ClinGen | rs1859345 |
| ebi | rs1859345 |
| HLI | rs1859345 |
| Exac | rs1859345 |
| Gnomad | rs1859345 |
| Varsome | rs1859345 |
| LitVar | rs1859345 |
| Map | rs1859345 |
| PheGenI | rs1859345 |
| Biobank | rs1859345 |
| 1000 genomes | rs1859345 |
| hgdp | rs1859345 |
| ensembl | rs1859345 |
| geneview | rs1859345 |
| scholar | rs1859345 |
| rs1859345 | |
| pharmgkb | rs1859345 |
| gwascentral | rs1859345 |
| openSNP | rs1859345 |
| 23andMe | rs1859345 |
| SNPshot | rs1859345 |
| SNPdbe | rs1859345 |
| MSV3d | rs1859345 |
| GWAS Ctlg | rs1859345 |
| GMAF | 0.2241 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs1859345 is a SNP in the - get ready - "sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1" SPOCK1 gene.
A study of 477 Caucasian women, followed up by replication studies in another ~1,600 and also 1,300+ Chinese women, found that several linked SNPs in the SPOCK1 gene are associated with age at menarche. rs1859345 replicated across all groups studied (p < 10e-3), with the minor (C) allele associated with a (slightly) earlier age at menarche.[PMID 19282985
]
