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From SNPedia

Geno Mag Summary
(T;T) 0 common in clinvar
Make rs1883832(C;C)
Make rs1883832(C;T)
ReferenceGRCh38.p2 38.2/146
is asnp
is mentioned by
dbSNP (classic)rs1883832
1000 genomesrs1883832
GWAS Ctlgrs1883832
Max Magnitude0
? (C;C) (C;T) (T;T) 28

[PMID 18097708] Women with the TT genotype in rs1883832 had increased risk of osteopenia or osteoporosis.

[PMID 18287517OA-icon.png] rs1883832(T;T) influence lymphoma [odds ratio (OR)=1.6, 95% confidence interval (CI)=1.1-2.4]

[PMID 20473910OA-icon.png] A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis

[PMID 20504251] CD40-1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke

[PMID 20634952OA-icon.png] CD40: Novel Association with Crohn's Disease and Replication in Multiple Sclerosis Susceptibility

[PMID 20682661] Influence of CD40 rs1883832 Polymorphism in Susceptibility to and Clinical Manifestations of Biopsy-proven Giant Cell Arteritis

[PMID 22087016] CD40 gene polymorphisms confer risk of Behcet's disease but not of Vogt-Koyanagi-Harada syndrome in a Han Chinese population

[PMID 22302395] Influence of MIF, CD40, and CD226 polymorphisms on risk of rheumatoid arthritis

[PMID 18045485OA-icon.png] The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.

[PMID 18591382OA-icon.png] A novel polymorphism of the human CD40 receptor with enhanced function.

[PMID 18794853OA-icon.png] Common variants at CD40 and other loci confer risk of rheumatoid arthritis.

[PMID 19159017OA-icon.png] STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma.

[PMID 20577873] Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women.

[PMID 21091218] The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study.

[PMID 22077624] A CD40 single-nucleotide polymorphism affects the lymphocyte profiles in the bronchoalveolar lavage of Japanese patients with sarcoidosis.

[PMID 23166616OA-icon.png] Study of Association of CD40-CD154 Gene Polymorphisms with Disease Susceptibility and Cardiovascular Risk in Spanish Rheumatoid Arthritis Patients

[PMID 23256180] Association of genetic polymorphisms in CD40 with susceptibility to SLE in the Korean population

[PMID 23613777OA-icon.png] Association of SNPs of CD40 gene with multiple sclerosis in Russians.

[PMID 24828072OA-icon.png] The SNP rs1883832 in CD40 Gene and Risk of Atherosclerosis in Chinese Population: A Meta-Analysis

[PMID 25305459] Lack of association between CD40 polymorphisms and acute rejection in German liver transplant recipients

[PMID 25373542] Associations of rs4810485 and rs1883832 polymorphisms of CD40 gene with susceptibility and clinical findings of Behçet's disease

[PMID 25802187] Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B

[PMID 26474561OA-icon.png] The association of CD40 polymorphisms with CD40 serum levels and risk of systemic lupus erythematosus

[PMID 26545336] The Role of CD40 and CD40L in Bone Mineral Density and in Osteoporosis Risk: A genetic and functional study

[PMID 26823861OA-icon.png] CD40 -1C>T polymorphism and the risk of lung cancer in a Chinese population.

[PMID 26957242] [Association of SNP of leukocyte differentiation antigen-CD40 gene and its serum level with ischemic stroke].

[PMID 28590502OA-icon.png] A SNP in 5' untranslated region of CD40 gene is associated with an increased risk of ischemic stroke in a Chinese population: a case-control study.

[PMID 28678751] Association between CD40 rs1883832 and immune-related diseases susceptibility: a meta-analysis.

Risk rs1883832(C;C)
Alt rs1883832(C;C)
Reference Rs1883832(T;T)
Significance Non-pathogenic
Disease Immunodeficiency with Hyper-IgM not specified
Variation info
Gene CD40
CLNDBN Immunodeficiency with Hyper-IgM not specified
Reversed 0
HGVS NC_000020.10:g.44746982T>C
CLNACC RCV000348388.1, RCV000456068.1,

[PMID 29254239OA-icon.png] Association between CD40 rs1883832 and immune-related diseases susceptibility: A meta-analysis.

[PMID 29780830OA-icon.png] The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels.

[PMID 30223781OA-icon.png] Correlation between CTLA-4 and CD40 gene polymorphisms and their interaction in graves' disease in a Chinese Han population.

[PMID 30374748] The association of CD40 polymorphism (rs1883832C/T) and soluble CD40 with the risk of systemic lupus erythematosus among Egyptian patients.

[PMID 31373353] Functional association of a CD40 gene single nucleotide polymorphism with the pathogenesis of coronary heart disease.

[PMID 31183392OA-icon.png] Analysis of Genetic Variation in CD40 and CD40L: Relationship with mRNA Relative Expression and Soluble Proteins in Acute Coronary Syndrome.

[PMID 32018016] Impact of CD40 gene polymorphisms on the risk of immune thrombocytopenic purpura.