rs1927911

minus

Geno	Mag	Summary
(C;C)		normal
(C;T)		0.88x lower risk of nonfatal myocardial infarction
(G;G)	0
(T;T)		0.88x lower risk of nonfatal myocardial infarction

Reference

GRCh38 38.1/141

Chromosome

9

Position

117707776

Gene

TLR4

is a	snp
is	mentioned by
dbSNP	rs1927911
dbSNP (classic)	rs1927911
ClinGen	rs1927911
ebi	rs1927911
HLI	rs1927911
Exac	rs1927911
Gnomad	rs1927911
Varsome	rs1927911
LitVar	rs1927911
Map	rs1927911
PheGenI	rs1927911
Biobank	rs1927911
1000 genomes	rs1927911
hgdp	rs1927911
ensembl	rs1927911
geneview	rs1927911
scholar	rs1927911
google	rs1927911
pharmgkb	rs1927911
gwascentral	rs1927911
openSNP	rs1927911
23andMe	rs1927911
SNPshot	rs1927911
SNPdbe	rs1927911
MSV3d	rs1927911
GWAS Ctlg	rs1927911

GMAF

0.3857

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

The rs1927911(T) allele was associated with a lower risk of nonfatal myocardial infarction (odds ratio 0.88, CI: 0.77 - 0.99) in 848 patients composed of both postmenopausal women and hypertensive men/women.[PMID 18549840 ]

[PMID 23936790 ] Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients

[PMID 19380025] The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men

[PMID 20685742] Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma

[PMID 21081146] Impact of Toll-like receptor 4 polymorphisms on risk of cancer

[PMID 21921986 ] Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population

[PMID 22272615] Common variants in toll-like receptor 4 confer susceptibility to Alzheimer's disease in a Han Chinese population

[PMID 22238472 ] Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease

[PMID 17699831 ] Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

[PMID 18298826 ] Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol.

[PMID 18396467 ] Genetic variation and haplotype structures of innate immunity genes in eastern India.

[PMID 18422738 ] Study of Toll-like receptor gene loci in sarcoidosis.

[PMID 18586872] Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma.

[PMID 19131814 ] Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study.

[PMID 19500628] Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis.

[PMID 19503741 ] Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.

[PMID 19567509 ] Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.

[PMID 19586676 ] Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.

[PMID 19753309 ] SOD2 gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.

[PMID 20011079 ] Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan.

[PMID 20200442 ] Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.

[PMID 20227302] Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.

[PMID 20463618 ] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 21403649] Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemia.

[PMID 23084080] The TLR4 gene polymorphisms and susceptibility to cancer: A systematic review and meta-analysis

[PMID 23639307] Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study

[PMID 24365597] Polymorphisms of the TLR4 gene and risk of gastric cancer

[PMID 22525209] Common polymorphisms in TLR4 gene associated with susceptibility to pulmonary tuberculosis in the Sudanese.

[PMID 22831837] Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma.

[PMID 24929142] Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer

[PMID 25216863] Association between Toll-like receptor 4 and interleukin 17 gene polymorphisms and colorectal cancer susceptibility in Northeast China

[PMID 25590839 ] TLR4 rs1927911, but Not TLR2 rs5743708, Is Associated With Atherosclerotic Cerebral Infarction in the Southern Han Population: A Case-Control Study

[PMID 25840711 ] Interactions between innate immunity genes and early-life risk factors in allergic rhinitis

[PMID 25908385] Association of TLR4 gene polymorphisms with sporadic Parkinson's disease in a Han Chinese population

[PMID 25947554] The association between toll-like receptor 4 polymorphisms and diabetic retinopathy in Chinese patients with type 2 diabetes

[PMID 25360682 ] Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis

[PMID 31772831 ] TLR4 polymorphisms may increase susceptibility to periodontitis in Pg-positive individuals.

[PMID 32871478] Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.