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From SNPedia

Geno Mag Summary
(C;C) normal
(C;T) 0.88x lower risk of nonfatal myocardial infarction
(G;G) 0
(T;T) 0.88x lower risk of nonfatal myocardial infarction
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs1927911
1000 genomesrs1927911
GWAS Ctlgrs1927911
Max Magnitude0
? (C;C) (C;T) (T;T) 28

The rs1927911(T) allele was associated with a lower risk of nonfatal myocardial infarction (odds ratio 0.88, CI: 0.77 - 0.99) in 848 patients composed of both postmenopausal women and hypertensive men/women.[PMID 18549840OA-icon.png]

[PMID 23936790OA-icon.png] Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients

[PMID 19380025] The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men

[PMID 20685742] Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma

[PMID 21081146] Impact of Toll-like receptor 4 polymorphisms on risk of cancer

[PMID 21921986OA-icon.png] Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population

[PMID 22272615] Common variants in toll-like receptor 4 confer susceptibility to Alzheimer's disease in a Han Chinese population

[PMID 22238472OA-icon.png] Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease

[PMID 17699831OA-icon.png] Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

[PMID 18298826OA-icon.png] Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol.

[PMID 18396467OA-icon.png] Genetic variation and haplotype structures of innate immunity genes in eastern India.

[PMID 18422738OA-icon.png] Study of Toll-like receptor gene loci in sarcoidosis.

[PMID 18586872] Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma.

[PMID 19131814OA-icon.png] Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study.

[PMID 19500628] Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis.

[PMID 19503741OA-icon.png] Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.

[PMID 19567509OA-icon.png] Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.

[PMID 19586676OA-icon.png] Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.

[PMID 19753309OA-icon.png] SOD2 gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.

[PMID 20011079OA-icon.png] Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan.

[PMID 20200442OA-icon.png] Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.

[PMID 20227302] Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.

[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 21403649] Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemia.

[PMID 23084080] The TLR4 gene polymorphisms and susceptibility to cancer: A systematic review and meta-analysis

[PMID 23639307] Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study

[PMID 24365597] Polymorphisms of the TLR4 gene and risk of gastric cancer

[PMID 22525209] Common polymorphisms in TLR4 gene associated with susceptibility to pulmonary tuberculosis in the Sudanese.

[PMID 22831837] Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma.

[PMID 24929142] Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer

[PMID 25216863] Association between Toll-like receptor 4 and interleukin 17 gene polymorphisms and colorectal cancer susceptibility in Northeast China

[PMID 25590839OA-icon.png] TLR4 rs1927911, but Not TLR2 rs5743708, Is Associated With Atherosclerotic Cerebral Infarction in the Southern Han Population: A Case-Control Study

[PMID 25840711OA-icon.png] Interactions between innate immunity genes and early-life risk factors in allergic rhinitis

[PMID 25908385] Association of TLR4 gene polymorphisms with sporadic Parkinson's disease in a Han Chinese population

[PMID 25947554] The association between toll-like receptor 4 polymorphisms and diabetic retinopathy in Chinese patients with type 2 diabetes

[PMID 25360682OA-icon.png] Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis

[PMID 31772831OA-icon.png] TLR4 polymorphisms may increase susceptibility to periodontitis in Pg-positive individuals.

[PMID 32871478] Polymorphisms and haplotypes of TLR4, TLR9 and CYP1A1 genes possibly interfere with high-risk human papillomavirus infection and cervical cancer susceptibility in Jharkhand, India.