rs1954787
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | ~10% more likely to respond to citalopram | |
| (C;T) | 0 | normal risk |
| (T;T) | 2 | ~10% less likely to respond to citalopram |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 120792654 |
| Gene | GRIK4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1954787 |
| dbSNP (classic) | rs1954787 |
| ClinGen | rs1954787 |
| ebi | rs1954787 |
| HLI | rs1954787 |
| Exac | rs1954787 |
| Gnomad | rs1954787 |
| Varsome | rs1954787 |
| LitVar | rs1954787 |
| Map | rs1954787 |
| PheGenI | rs1954787 |
| Biobank | rs1954787 |
| 1000 genomes | rs1954787 |
| hgdp | rs1954787 |
| ensembl | rs1954787 |
| geneview | rs1954787 |
| scholar | rs1954787 |
| rs1954787 | |
| pharmgkb | rs1954787 |
| gwascentral | rs1954787 |
| openSNP | rs1954787 |
| 23andMe | rs1954787 |
| SNPshot | rs1954787 |
| SNPdbe | rs1954787 |
| MSV3d | rs1954787 |
| GWAS Ctlg | rs1954787 |
| GMAF | 0.4679 |
| Max Magnitude | 2 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs1954787, located in an intron of the GRIK4 gene, was found to be associated with a somewhat increased rate of successful response to treatment of depression with the drug citalopram. [PMID 17671280]
From the abstract of this article:
"The effect size of (this) GRIK4 marker alone was modest, but homozygote carriers of the treatment-response-associated marker alleles of both the GRIK4 and HTR2A (see rs7997012) genes were 23% less likely to experience nonresponse to (citalopram) treatment relative to participants who did not carry any of these marker alleles."
- See also Anxiety Blog posting
[PMID 19924111
] Polymorphisms in GRIK4, HTR2A, and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21208417] International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol.
[PMID 23394390] Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response
| ClinVar | |
|---|---|
| Risk | Rs1954787(C;C) |
| Alt | Rs1954787(C;C) |
| Reference | Rs1954787(T;T) |
| Significance | Drug-response |
| Disease | antidepressants response - Efficacy citalopram response - Efficacy |
| Variation | info |
| Gene | GRIK4 |
| CLNDBN | antidepressants response - Efficacy citalopram response - Efficacy |
| Reversed | 0 |
| HGVS | NC_000011.9:g.120663363T>C |
| CLNSRC | PharmGKB Clinical Annotation |
| CLNACC | RCV000211180.1, RCV000211426.1, |
