rs198389
| Orientation | plus |
| Stabilized | plus |
| Make rs198389(A;A) |
| Make rs198389(A;G) |
| Make rs198389(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 11859214 |
| Gene | NPPB |
| is a | snp |
| is | mentioned by |
| dbSNP | rs198389 |
| dbSNP (classic) | rs198389 |
| ClinGen | rs198389 |
| ebi | rs198389 |
| HLI | rs198389 |
| Exac | rs198389 |
| Gnomad | rs198389 |
| Varsome | rs198389 |
| LitVar | rs198389 |
| Map | rs198389 |
| PheGenI | rs198389 |
| Biobank | rs198389 |
| 1000 genomes | rs198389 |
| hgdp | rs198389 |
| ensembl | rs198389 |
| geneview | rs198389 |
| scholar | rs198389 |
| rs198389 | |
| pharmgkb | rs198389 |
| gwascentral | rs198389 |
| openSNP | rs198389 |
| 23andMe | rs198389 |
| SNPshot | rs198389 |
| SNPdbe | rs198389 |
| MSV3d | rs198389 |
| GWAS Ctlg | rs198389 |
| GMAF | 0.3173 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 17719005] Brain natriuretic peptide (BNP) has been widely used for the diagnosis and prognostic evaluation of chronic heart failure (CHF) rs198389 (T-381C), plasma BNP levels among the three genotypic categories, i.e., 2189 homozygous T-allele carriers (BNP 26.4+/-0.6pg/ml), 697 heterozygous carriers (35.0+/-1.1pg/ml), and 52 homozygous C-allele carriers (46.0+/-4.1pg/ml) indicated a co-dominant effect of the minor C-allele on elevating plasma BNP levels (P<0.0001)
[PMID 19326473
] Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.
[PMID 19377085] The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49,279 subjects
[PMID 19413180] SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension
[PMID 19631175] Natriuretic peptides in the diagnosis and management of chronic heart failure.
[PMID 21273288] Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.
[PMID 21276798] Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes.
[PMID 21364112] The effect of the brain-type natriuretic peptide single-nucleotide polymorphism rs198389 on test characteristics of common assays.
[PMID 23315043] Common genetic variants of the natriuretic peptide gene locus are not associated with heart failure risk in participants in the EPIC-Norfolk study
[PMID 23288489] Prospective evaluation of B-type natriuretic peptide concentrations and the risk of type 2 diabetes in women.
[PMID 25934190] Examination of the brain natriuretic peptide rs198389 single-nucleotide polymorphism on type 2 diabetes mellitus and related phenotypes in an Algerian population
[PMID 26908625] Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome.
[PMID 28275418] Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis.
