|(A;A)||1.5||rare genotype, on a triallelic snp|
|(G;G)||1||normal. better response to atorvastatin. greater severity of delusions in male schizophrenics.|
|(T;T)||1.5||4x higher risk for lung cancer|
The rs2032582(T) variant allele yields a 2.6 fold higher risk of developing lung cancer, and in particular, the type of lung cancer called squamous cell carcinoma (CI 1.7-4.0, P < .001) in white Spanish smokers. There appears to be little gene dosage effect, since homozygous rs2032582(T;T) carriers shoulder almost all the risk (odds ratio 6.75 compared to (A;A) homozygotes, CI 3.0-15.2). This risk is also the same in light or heavy smokers. [PMID 17120199]
A study of 98 methadone-maintaining patients concluded that the higher (>150 mg/day) and lower (< or =150 mg/day) methadone dose groups differed significantly in their rs1128503 status (experiment-wise p = 0.0325). Furthermore, individuals with the 3-locus genotype pattern (T;T)-(T;T)-(T;T) for SNPs rs1045642, rs2032582 and rs1128503, respectively, had an approximately 5-fold chance of requiring the 'higher' methadone dose, while individuals heterozygous for these three SNPs have an approximately 3-fold chance of stabilizing at the 'lower' methadone dose (point-wise p-value = 0.026).[PMID 18424454]
OMIM also reports an association with Crohn's disease.
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|Disease||not specified Ondansetron response - Efficacy simvastatin response - Efficacy Ovarian Neoplasms|
|CLNDBN||not specified ondansetron response - Efficacy simvastatin response - Efficacy Ovarian Neoplasms|
|CLNSRC||HGMD PharmGKB Clinical Annotation UniProtKB (protein)|
|CLNACC||RCV000152717.3, RCV000211207.1, RCV000211425.1, RCV000152713.3, RCV000429867.1,|
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