rs2069837
| Orientation | plus |
| Stabilized | plus |
| Make rs2069837(A;A) |
| Make rs2069837(A;G) |
| Make rs2069837(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 7 |
| Position | 22728408 |
| Gene | IL6, LOC541472 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2069837 |
| dbSNP (classic) | rs2069837 |
| ClinGen | rs2069837 |
| ebi | rs2069837 |
| HLI | rs2069837 |
| Exac | rs2069837 |
| Gnomad | rs2069837 |
| Varsome | rs2069837 |
| LitVar | rs2069837 |
| Map | rs2069837 |
| PheGenI | rs2069837 |
| Biobank | rs2069837 |
| 1000 genomes | rs2069837 |
| hgdp | rs2069837 |
| ensembl | rs2069837 |
| geneview | rs2069837 |
| scholar | rs2069837 |
| rs2069837 | |
| pharmgkb | rs2069837 |
| gwascentral | rs2069837 |
| openSNP | rs2069837 |
| 23andMe | rs2069837 |
| SNPshot | rs2069837 |
| SNPdbe | rs2069837 |
| MSV3d | rs2069837 |
| GWAS Ctlg | rs2069837 |
| GMAF | 0.1065 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
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In a study of 1,757 cases of Alzheimer's disease and 6,295 controls, an interaction was replicated between IL6 genotype rs2069837(A;A) and IL10 genotype rs1800871(C;C). The synergy factor (SF) was 1.63 (CI: 1.10-2.41, p = 0.01), controlling for age, gender and ApoE4 genotype.[PMID 19698145
]
[PMID 22272811] Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease
[PMID 17847004] Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance.
[PMID 18216863] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.
[PMID 18436879] Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study.
[PMID 18496509] An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.
[PMID 18500540] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.
[PMID 19267250] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
[PMID 19387461] Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection.
[PMID 19401628] Host genetics, steatosis and insulin resistance among African Americans and Caucasian Americans with hepatitis C virus genotype-1 infection.
[PMID 19729864] Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.
[PMID 23088295] A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels
[PMID 23180271] Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women
[PMID 23415255] Association of Interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: a case-control study
[PMID 24903966] The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy
[PMID 25789467] Analysis of IL-6, STAT3 and HSPA1L Gene Polymorphisms in Anti-Tuberculosis Drug-Induced Hepatitis in a Nested Case-Control Study
[PMID 27535759] Polymorphisms of the interleukin 6 gene and additional gene-gene interaction contribute to cervical cancer susceptibility in Eastern Chinese women.
[PMID 28160070] Single nucleotide polymorphisms of IL12B are associated with Takayasu arteritis in Chinese Han population.
[PMID 29662655] Association of IL4, IL6, and IL10 polymorphisms with pulmonary tuberculosis in a Tibetan Chinese population.
[PMID 31082334] [Correlation between interleukin-6 single nucleotide polymorphism and the occurrence and prognosis of hepatitis B virus-associated acute-on-chronic liver failure].
[PMID 31288714] Polymorphisms of the Highly Expressed IL-6 Gene in the Papillary Thyroid Cancer Susceptibility Among Chinese.
[PMID 32266003] Interleukin-6 polymorphisms in HCC patients chronically infected with HCV.
