rs2070045
| Orientation | plus |
| Stabilized | plus |
| Make rs2070045(G;G) |
| Make rs2070045(G;T) |
| Make rs2070045(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 121577381 |
| Gene | SORL1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2070045 |
| dbSNP (classic) | rs2070045 |
| ClinGen | rs2070045 |
| ebi | rs2070045 |
| HLI | rs2070045 |
| Exac | rs2070045 |
| Gnomad | rs2070045 |
| Varsome | rs2070045 |
| LitVar | rs2070045 |
| Map | rs2070045 |
| PheGenI | rs2070045 |
| Biobank | rs2070045 |
| 1000 genomes | rs2070045 |
| hgdp | rs2070045 |
| ensembl | rs2070045 |
| geneview | rs2070045 |
| scholar | rs2070045 |
| rs2070045 | |
| pharmgkb | rs2070045 |
| gwascentral | rs2070045 |
| openSNP | rs2070045 |
| 23andMe | rs2070045 |
| SNPshot | rs2070045 |
| SNPdbe | rs2070045 |
| MSV3d | rs2070045 |
| GWAS Ctlg | rs2070045 |
| GMAF | 0.3214 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
SNP rs2070045, a variant of the SORL1 gene, has been reported to be associated with Alzheimer's disease. [PMID 17220890
]
However, a subsequent study of over 2,000 patients found a weak (at best) association. [PMID 17949987]
[PMID 18562096] No association of SORL1 SNPs with Alzheimer's disease.
[PMID 18713574] The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.
[PMID 18938222] Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues.
[PMID 19064752] Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.
[PMID 19362127] Endophenotypes in normal brain morphology and Alzheimer's disease: a review.
[PMID 19368828] Association of SORL1 gene variants with Alzheimer's disease.
[PMID 19906263] Use of genetic variation as biomarkers for Alzheimer's disease.
[PMID 20061642] Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia.
[PMID 20574532] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
[PMID 20625269] Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population.
[PMID 24083537] SORL1 genetic variants modulate risk of amnestic mild cognitive impairment in northern Han Chinese
[PMID 24309291] Association between the SORL1 rs2070045 polymorphism and Late-onset Alzheimer's disease: Interaction with the ApoE genotype in the Chinese Han population
[PMID 23318115] Sortilin receptor 1 predicts longitudinal cognitive change.
[PMID 26268719] Sex Moderates the Effects of the Sorl1 Gene rs2070045 Polymorphism on Cognitive Impairment and Disruption of the Cingulum Integrity in Healthy Elderly
[PMID 26611835] Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1.
