rs2070106
| Orientation | plus |
| Stabilized | plus |
| Make rs2070106(A;A) |
| Make rs2070106(A;G) |
| Make rs2070106(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 17 |
| Position | 41973846 |
| Gene | CNP |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2070106 |
| dbSNP (classic) | rs2070106 |
| ClinGen | rs2070106 |
| ebi | rs2070106 |
| HLI | rs2070106 |
| Exac | rs2070106 |
| Gnomad | rs2070106 |
| Varsome | rs2070106 |
| LitVar | rs2070106 |
| Map | rs2070106 |
| PheGenI | rs2070106 |
| Biobank | rs2070106 |
| 1000 genomes | rs2070106 |
| hgdp | rs2070106 |
| ensembl | rs2070106 |
| geneview | rs2070106 |
| scholar | rs2070106 |
| rs2070106 | |
| pharmgkb | rs2070106 |
| gwascentral | rs2070106 |
| openSNP | rs2070106 |
| 23andMe | rs2070106 |
| SNPshot | rs2070106 |
| SNPdbe | rs2070106 |
| MSV3d | rs2070106 |
| GWAS Ctlg | rs2070106 |
| GMAF | 0.2626 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
Based on a study of 790 individuals from 245 nuclear families (220 families were European Caucasian; 300 of the probands had a diagosis of schizophrenia), the rs2070106(G) allele was overtransmitted to affected offspring.[PMID 18496213]
This actually conflicts with a previous report [PMID 16389193] in which the rs2070106(A) allele was identified (also in Caucasians) in a combined gene association/expression study as associated with schizophrenia.
This is either a case of the "flip-flop" phenomenon [PMID 17273975
] in which multilocus effects and variation in interlocus correlations reverse a previously reported association, or perhaps more likely, a false positive.
[PMID 17306456] Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population.
[PMID 17964117] Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.
[PMID 18289148] Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia.
[PMID 19348671] No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis.
[PMID 22473874] A myelin gene causative of a catatonia-depression syndrome upon aging.
[PMID 23032943] The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives
