rs2073618
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common in clinvar |
| Make rs2073618(C;G) |
| Make rs2073618(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 8 |
| Position | 118951813 |
| Gene | COLEC10, TNFRSF11B |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2073618 |
| dbSNP (classic) | rs2073618 |
| ClinGen | rs2073618 |
| ebi | rs2073618 |
| HLI | rs2073618 |
| Exac | rs2073618 |
| Gnomad | rs2073618 |
| Varsome | rs2073618 |
| LitVar | rs2073618 |
| Map | rs2073618 |
| PheGenI | rs2073618 |
| Biobank | rs2073618 |
| 1000 genomes | rs2073618 |
| hgdp | rs2073618 |
| ensembl | rs2073618 |
| geneview | rs2073618 |
| scholar | rs2073618 |
| rs2073618 | |
| pharmgkb | rs2073618 |
| gwascentral | rs2073618 |
| openSNP | rs2073618 |
| 23andMe | rs2073618 |
| SNPshot | rs2073618 |
| SNPdbe | rs2073618 |
| MSV3d | rs2073618 |
| GWAS Ctlg | rs2073618 |
| GMAF | 0.3567 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 20231205] Genetic Variations in Genes Encoding RANK, RANKL, and OPG in Rheumatoid Arthritis: A Case-Control Study
[PMID 22079369] TNFRSF11B gene haplotype and its association with bone mineral density variations in postmenopausal Mexican-Mestizo women
[PMID 21964949
] Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men
[PMID 16583245] Genetic susceptibility to hip arthroplasty failure--association with the RANK/OPG pathway.
[PMID 19458885] Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians.
[PMID 20205168] Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men.
[PMID 21396799] Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw.
[PMID 21411255] TNFRSF11B gene polymorphisms 1181G > C and 245T > G as well as haplotype CT influence bone mineral density in postmenopausal women.
[PMID 23369128] Genetic polymorphism of the OPG gene associated with breast cancer
[PMID 24130145] Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal maya-mestizo women
[PMID 24228244] SNP rs2073618 of the Osteoprotegerin Gene Is Associated with Diabetic Retinopathy in Slovenian Patients with Type 2 Diabetes
[PMID 24283361] Association Between Seven Common OPG Genetic Polymorphisms and Osteoporosis Risk: A Meta-Analysis
[PMID 23299915] Osteoprotegerin gene rs2073617 and rs3134069 polymorphisms in type 2 diabetes patients and sexspecific rs2073618 polymorphism as a risk factor for diabetic foot.
[PMID 23531404] Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women.
[PMID 25032118] Exclusion of TNFRSF11B as Candidate Gene for Otosclerosis in Campania Population
[PMID 25323794] TNFRSF11B gene polymorphisms, bone mineral density, and fractures in Slovak postmenopausal women
[PMID 25679449] A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results from a Candidate Gene Study
[PMID 26218592] RANKL and OPG Polymorphisms Are Associated with Aromatase Inhibitor-Related Musculoskeletal Adverse Events in Chinese Han Breast Cancer Patients
[PMID 26451891] RANK rs1805034 T>C Polymorphism Is Associated with Susceptibility to Gastric Cardia Adenocarcinoma in a Chinese Population
[PMID 26579581] Genetic and environmental predictors of chronic kidney disease in patients with type 2 diabetes and diabetic foot ulcer: a pilot study
| ClinVar | |
|---|---|
| Risk | rs2073618(G;G) |
| Alt | rs2073618(G;G) |
| Reference | Rs2073618(C;C) |
| Significance | Non-pathogenic |
| Disease | not specified Hyperphosphatasemia with bone disease |
| Variation | info |
| Gene | TNFRSF11B COLEC10 |
| CLNDBN | not specified Hyperphosphatasemia with bone disease |
| Reversed | 1 |
| HGVS | NC_000008.10:g.119964052G>C |
| CLNSRC | |
| CLNACC | RCV000250490.1, RCV000291754.1, |
[PMID 28244588] Investigation of OPG/RANK/RANKL Genes as a Genetic Marker for Cardiac abnormalities in Thalassemia Major Patients.
[PMID 30309792] Association of SNP-SNP Interactions Between RANKL, OPG, CHI3L1, and VDR Genes With Breast Cancer Risk in Egyptian Women.
[PMID 30624097] Association of VDR and OPG gene polymorphism with osteoporosis risk in Chinese postmenopausal women.
[PMID 31157557] Osteoprotegerin and osteopontin levels, but not gene polymorphisms, predict mortality in cardiovascular diseases.
[PMID 33572979] Association of RANKL and OPG Gene Polymorphism in Arab Women with and without Osteoporosis.
