rs210138

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)	0	common in complete genomics
(G;G)	2.7	Testicular Cancer

Make rs210138(A;G)

Reference

GRCh38 38.1/141

Chromosome

6

Position

33574761

Gene

BAK1

is a	snp
is	mentioned by
dbSNP	rs210138
dbSNP (classic)	rs210138
ClinGen	rs210138
ebi	rs210138
HLI	rs210138
Exac	rs210138
Gnomad	rs210138
Varsome	rs210138
LitVar	rs210138
Map	rs210138
PheGenI	rs210138
Biobank	rs210138
1000 genomes	rs210138
hgdp	rs210138
ensembl	rs210138
geneview	rs210138
scholar	rs210138
google	rs210138
pharmgkb	rs210138
gwascentral	rs210138
openSNP	rs210138
23andMe	rs210138
SNPshot	rs210138
SNPdbe	rs210138
MSV3d	rs210138
GWAS Ctlg	rs210138

GMAF

0.241

Max Magnitude

2.7

?	(A;A) (A;G) (G;G)	28

23andMe blog each rs210138(G) was found to increase the odds of testicular cancer by 1.5x

GWAS snp
PMID	[PMID 19483681]
Trait	Testicular germ cell tumor
Title	A genome-wide association study of testicular germ cell tumor
Risk Allele	G
P-val	1E-13
Odds Ratio	1.50 [1.28-1.75]

OMIM	273300
Desc
Variant
Related	also

[PMID 21617256] Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour

[PMID 22072546] Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.

GWAS snp
PMID	[PMID 23666239]
Trait	Testicular germ cell tumor
Title	Meta-analysis identifies four new loci associated with testicular germ cell tumor.
Risk Allele	G
P-val	3E-7
Odds Ratio	1.62 [1.35-1.95]

GWAS snp
PMID	[PMID 23666240]
Trait	Testicular germ cell tumor
Title	Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
Risk Allele	G
P-val	2E-24
Odds Ratio	1.44 [1.30-1.61]

[PMID 28295819] Variants in BAK1, SPRY4, and GAB2 are Associated with Pediatric Germ Cell Tumors: A Report from the Children's Oncology Group.