Testicular cancer
From Wikipedia:
Testicular cancer is a cancer that develops in the testicles. In the United States, between 7,500 and 8,000 diagnoses of testicular cancer are made each year, with a man's lifetime risk being roughly 1 in 250.
In 2015, a polygenic risk score including 4 new testicular cancer SNPs (or their proxies; all by GWAS) plus 21 previously found ones concluded that 1% of men scoring in the highest risk category had a 10-fold higher risk of testicular cancer, "although that still adds up to only around a 5 percent (one in 20) chance of developing testicular cancer" over one's life, according to the senior author.[PMID 26503584
] The 25 SNPs used in this score (and the associated candidate gene) were:
| SNP | Candidate Gene |
|---|---|
| rs995030 | KITLG |
| rs210138 | BAK1 |
| rs4624820 | SPRY4 |
| rs4635969 | TERT |
| rs755383 | DMRT1 |
| rs2900333 | ATF7IP |
| rs8046148 | HEATR3 |
| rs2839243 | non-coding |
| rs3805663 | CATSPER3 |
| rs10510452 | DAZL |
| rs2720460 | CENPE |
| rs7010162 | PRDM14 |
| rs9905704 | RAD51C |
| rs3790672 | non-coding |
| rs2072499 | PMF1 |
| rs4888262 | RFWD3 |
| rs12699477 | MAD1L1 |
| rs17021463 | HPGDS |
| rs1510272 | SSR3 |
| rs7501939 | HNF1B |
| rs2195987 | non-coding |
| rs11705932 | TFPD2 |
| rs7107174 | GAB2 |
| rs4561483 | BCAR4 |
| rs55637647 | ZFPM1 |
Other SNPs which may increase (or decrease) risk for testicular cancer include:
- rs3782179 and rs4474514, in the c-kit ligand KITLG gene
- rs4324715 and rs6897876, near the SPRY4 gene
SNPs which may affect the success of chemotherapeutic treatment for testicular cancer include:
