rs2231142(A;A)
From SNPedia
| causes gout |
| Is a | genotype |
| of | rs2231142 |
| Gene | ABCG2 |
| Chromosome | 4 |
| Position | 88,131,171 |
| mentioned | by |
| Magnitude | 3.5 |
| Repute | Bad |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 3.5 | causes gout |
| (A;C) | 2.1 | 1.74x increased gout risk; gefinitib takers 4x more susceptible to diarrhea |
| (C;C) | 0 | normal |
At least 10% of all gout cases in whites are attributable to this causal variant. [PMID 19506252]
[PMID 26810134] ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout.
This variation influences uric acid concentrations and causes 53% reduced urate transport rates compared to wild-type.
Reduced transport of chemotherapeutic agents by this mutation [PMID 18370855].
Other reported effects include 4x higher risk of diarrhea when taking gefitinib and 2x effectiveness of rosuvastatin.
