rs2287218
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2.6 | Slightly higher risk for CHD and IS |
| (A;G) | 1.6 | Slightly higher risk for CHD and IS |
| (G;G) | 0 | common/normal |
| Reference | GRCh38.p7 38.3/151 |
| Chromosome | 12 |
| Position | 109581533 |
| Gene | MVK |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2287218 |
| dbSNP (classic) | rs2287218 |
| ClinGen | rs2287218 |
| ebi | rs2287218 |
| HLI | rs2287218 |
| Exac | rs2287218 |
| Gnomad | rs2287218 |
| Varsome | rs2287218 |
| LitVar | rs2287218 |
| Map | rs2287218 |
| PheGenI | rs2287218 |
| Biobank | rs2287218 |
| 1000 genomes | rs2287218 |
| hgdp | rs2287218 |
| ensembl | rs2287218 |
| geneview | rs2287218 |
| scholar | rs2287218 |
| rs2287218 | |
| pharmgkb | rs2287218 |
| gwascentral | rs2287218 |
| openSNP | rs2287218 |
| 23andMe | rs2287218 |
| SNPshot | rs2287218 |
| SNPdbe | rs2287218 |
| MSV3d | rs2287218 |
| GWAS Ctlg | rs2287218 |
| Max Magnitude | 2.6 |
Based on a study of 1764 unrelated Southern Han Chinese subjects (CHD, 583; IS, 555; and healthy controls, 626), rs2287218(A) allele carriers had an increased risk of coronary heart disease and ischemic stroke (CHD: OR = 1.674, CI: 1.25-2.25, p = 0.001 for AG/AA vs. GG genotypes; IS: OR = 1.890, CI: 1.36-2.47, p = 0.001 for AG/AA vs. GG genotypes). The authors hypothesize that rs2287218 is likely to increase the risk of CHD and IS by decreasing serum HDL-C levels.[PMID 30101835]
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
