rs2297508
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | normal | |
| (C;G) | 1.08x increased risk for T2D | |
| (G;G) | 1.08x increased risk for T2D |
| Reference | GRCh38 38.1/141 |
| Chromosome | 17 |
| Position | 17812003 |
| Gene | SREBF1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2297508 |
| dbSNP (classic) | rs2297508 |
| ClinGen | rs2297508 |
| ebi | rs2297508 |
| HLI | rs2297508 |
| Exac | rs2297508 |
| Gnomad | rs2297508 |
| Varsome | rs2297508 |
| LitVar | rs2297508 |
| Map | rs2297508 |
| PheGenI | rs2297508 |
| Biobank | rs2297508 |
| 1000 genomes | rs2297508 |
| hgdp | rs2297508 |
| ensembl | rs2297508 |
| geneview | rs2297508 |
| scholar | rs2297508 |
| rs2297508 | |
| pharmgkb | rs2297508 |
| gwascentral | rs2297508 |
| openSNP | rs2297508 |
| 23andMe | rs2297508 |
| SNPshot | rs2297508 |
| SNPdbe | rs2297508 |
| MSV3d | rs2297508 |
| GWAS Ctlg | rs2297508 |
| GMAF | 0.4578 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs2297508 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes.
A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.17 (CI: 1.05-1.30, p=0.003) for the minor (risk) allele, rs2297508(C). A meta-analysis included other published studies concluded the odds ratio was 1.08 (CI: 1.03-1.14, p=0.001).[PMID 18192539]
[PMID 18692268] type-2 diabetes rs2297508(C) and rs11868035(C)
[PMID 21178094] A Two-Step Association Study Identifies CAV2 rs2270188 Single Nucleotide Polymorphism Interaction with Fat Intake in Type 2 Diabetes Risk
[PMID 21609284] Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth
[PMID 22678801] [Association of sterol regulatory element binding protein-1c genetic polymorphisms rs2297508 and rs11868035 with type 2 diabetes mellitus in Gansu Han and Dongxiang population]
[PMID 17160088] The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population.
[PMID 24152445
] Identification of Combined Genetic Determinants of Liver Stiffness within the SREBP1c-PNPLA3 Pathway
[PMID 24614076] Single Nucleotide Polymorphism of SREBF-1 Gene Associated with an Increased Risk of Endometrial Cancer in Chinese Women
[PMID 31490983] SREBF1c and SREBF2 gene polymorphisms are associated with acute coronary syndrome and blood lipid levels in Mexican population.
