rs11868035
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.19x increased risk for T2D | |
| (A;G) | 1.19x increased risk for T2D | |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 17 |
| Position | 17811787 |
| Gene | RAI1, SREBF1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11868035 |
| dbSNP (classic) | rs11868035 |
| ClinGen | rs11868035 |
| ebi | rs11868035 |
| HLI | rs11868035 |
| Exac | rs11868035 |
| Gnomad | rs11868035 |
| Varsome | rs11868035 |
| LitVar | rs11868035 |
| Map | rs11868035 |
| PheGenI | rs11868035 |
| Biobank | rs11868035 |
| 1000 genomes | rs11868035 |
| hgdp | rs11868035 |
| ensembl | rs11868035 |
| geneview | rs11868035 |
| scholar | rs11868035 |
| rs11868035 | |
| pharmgkb | rs11868035 |
| gwascentral | rs11868035 |
| openSNP | rs11868035 |
| 23andMe | rs11868035 |
| SNPshot | rs11868035 |
| SNPdbe | rs11868035 |
| MSV3d | rs11868035 |
| GWAS Ctlg | rs11868035 |
| GMAF | 0.4692 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs11868035 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes. A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.19 (CI: 1.07-1.33, p=0.002) for the minor (risk) allele, rs11868035(A), in the orientation as in dbSNP. [PMID 18192539]
[PMID 18692268] type-2 diabetes rs2297508(C) and rs11868035(C)
This SNP rs11868035 and rs1057217 are associated with increased risk of schizophrenia in German and Scandinavian samples. [PMID 18936756]
This SNP and rs6812193 are reported to affect risk of Parkinson's disease. [PMID 21738487
] plos
[PMID 22531747] Association study between two novel single nucleotide polymorphisms and sporadic Parkinson's disease in Chinese Han population
[PMID 22678801] [Association of sterol regulatory element binding protein-1c genetic polymorphisms rs2297508 and rs11868035 with type 2 diabetes mellitus in Gansu Han and Dongxiang population]
[PMID 17019602] Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes.
[PMID 24152445] Identification of Combined Genetic Determinants of Liver Stiffness within the SREBP1c-PNPLA3 Pathway
[PMID 29128630] Association analysis of SNP rs11868035 in SREBF1 with sporadic Parkinson's disease, sporadic amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population.
[PMID 31490983] SREBF1c and SREBF2 gene polymorphisms are associated with acute coronary syndrome and blood lipid levels in Mexican population.
