rs6812193

plus

Geno	Mag	Summary
(C;C)	1.1	slightly higher risk of developing Parkinson's Disease for caucasians
(C;T)	1	normal risk of developing Parkinson's Disease
(T;T)	1.5	Slightly decreased risk of developing Parkinson's Disease

Reference

GRCh38 38.1/141

Chromosome

4

Position

76277833

Gene	FAM47E, FAM47E-STBD1, LOC105377286

0.3007

1.5

(C;C) (C;T) (T;T)

28

People with two copies of the T allele at rs6812193 appear to have a slightly lower risk of Parkinson's disease. [PMID 21738487 ]

The same researchers identified another risk allele for Parkinson's disease at rs11868035. plos

GWAS snp
PMID	[PMID 19915575 ]
Trait	Parkinson's disease
Title	Genome-wide association study reveals genetic risk underlying Parkinson's disease
Risk Allele	T
P-val	4E-7
Odds Ratio	1.12 [NR]

[PMID 22531747] Association study between two novel single nucleotide polymorphisms and sporadic Parkinson's disease in Chinese Han population

[PMID 22465138] Association study of SCARB2 rs6812193 polymorphism with Parkinson's disease in Han Chinese.

[PMID 23419877 ] Is Parkinson disease associated with lysosomal integral membrane protein type-2?: Challenges in interpreting association data

[PMID 23473716] Association study of rs6812193 polymorphism with Parkinson's disease in a Greek population

[PMID 23408458] The role of SCARB2 as susceptibility factor in Parkinson's disease

[PMID 25929833] Parkinson's Disease Genetic Loci in Rapid Eye Movement Sleep Behavior Disorder