rs2297595

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(T;T)	0	common on affy axiom data

Make rs2297595(C;C)

Make rs2297595(C;T)

Reference

GRCh38 38.1/141

Chromosome

1

Position

97699535

Gene

DPYD

is a	snp
is	mentioned by
dbSNP	rs2297595
dbSNP (classic)	rs2297595
ClinGen	rs2297595
ebi	rs2297595
HLI	rs2297595
Exac	rs2297595
Gnomad	rs2297595
Varsome	rs2297595
LitVar	rs2297595
Map	rs2297595
PheGenI	rs2297595
Biobank	rs2297595
1000 genomes	rs2297595
hgdp	rs2297595
ensembl	rs2297595
geneview	rs2297595
scholar	rs2297595
google	rs2297595
pharmgkb	rs2297595
gwascentral	rs2297595
openSNP	rs2297595
23andMe	rs2297595
SNPshot	rs2297595
SNPdbe	rs2297595
MSV3d	rs2297595
GWAS Ctlg	rs2297595

GMAF

0.06612

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

ClinVar
Risk	rs2297595(C;C)
Alt	rs2297595(C;C)
Reference	Rs2297595(T;T)
Significance	Drug-response
Disease	not provided fluorouracil response - Toxicity/ADR capecitabine response - Toxicity/ADR not specified Dihydropyrimidine dehydrogenase deficiency
Variation	info
Gene	DPYD
CLNDBN	not provided fluorouracil response - Toxicity/ADR capecitabine response - Toxicity/ADR not specified Dihydropyrimidine dehydrogenase deficiency
Reversed	0
HGVS	NC_000001.10:g.98165091T>C
CLNSRC	PharmGKB Clinical Annotation UniProtKB (protein)
CLNACC	RCV000086499.1, RCV000211196.1, RCV000211377.1, RCV000245015.2, RCV000276917.1,

[PMID 26216193] Genotype-phenotype correlations in 5-fluorouracil metabolism: a candidate DPYD haplotype to improve toxicity prediction