rs2302009

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(G;G)	1.2	4.6x risk of eosinophilic esophagitis
(G;T)	1	normal
(T;T)	0	normal

Reference

GRCh38 38.1/141

Chromosome

7

Position

75769680

Gene

CCL26

is a	snp
is	mentioned by
dbSNP	rs2302009
dbSNP (classic)	rs2302009
ClinGen	rs2302009
ebi	rs2302009
HLI	rs2302009
Exac	rs2302009
Gnomad	rs2302009
Varsome	rs2302009
LitVar	rs2302009
Map	rs2302009
PheGenI	rs2302009
Biobank	rs2302009
1000 genomes	rs2302009
hgdp	rs2302009
ensembl	rs2302009
geneview	rs2302009
scholar	rs2302009
google	rs2302009
pharmgkb	rs2302009
gwascentral	rs2302009
openSNP	rs2302009
23andMe	rs2302009
SNPshot	rs2302009
SNPdbe	rs2302009
MSV3d	rs2302009
GWAS Ctlg	rs2302009

GMAF

0.264

Max Magnitude

1.2

?	(G;G) (G;T) (T;T)	28

rs2302009 is a SNP located in the 3' untranslated region of the CCL26 gene. This gene (and this SNP) were discovered to be strongly associated with 117 patients with eosinophilic esophagitis, a form of esophagitis (or inflammation of the esophagus) that shares many symptoms with gastroesophageal reflux disease (GERD). [PMID 16453027]

rs2302009(G) is the risk allele. The rs2302009(G;G) homozygous genotype is the most predisposed to developing eosinophilic esophagitis (odds ratio 4.55, CI 1.71–12.39). The heterozgyote (rs2302009(G;T)) genotype's risk was indistinguishable statistically from the normal rs23020099(T;T) genotype. [PMID 15453027]

OMIM	604697
Desc	ESOPHAGITIS, EOSINOPHILIC, SUSCEPTIBILITY TO
Variant	0001
Related	also

OMIM	610247
Desc	ESOPHAGITIS, EOSINOPHILIC
Variant
Related	also

[PMID 17848170] The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility.

[PMID 20808897] Disease-associated mutations that alter the RNA structural ensemble.