|asthma and atopic dermatitis|
rs2303067, a SNP in the SPINK5 gene, has been significantly associated with susceptibility to atopic dermatitis. [PMID 11544479]
The risk allele for rs2303067 is (A).
rs2303067 has also been associated with predisposition to asthma, [PMID 15005725]. From this study:
"A significant association between rs2303067 and the development of asthma was observed (OR 1.77; 95%CI: 1.02-3.06, P=0.041 for rs2303067(A;A) homozygotes). Atopic carriers of rs2303067 showed an increased risk for asthma and asthma symptoms (OR 2.06; 95%CI: 1.01-4.20, P=0.047). When children with a combination of asthma and atopic dermatitis were compared with normal controls, the rs2303067(A) genotype was more prevalent in the disease group (OR 4.56; 95%CI: 1.370-15.12, P=0.007)."
Atopy Dermatitis Asthma not specified Netherton syndrome
| Variation || info |
Atopy, susceptibility to Dermatitis, atopic, 6, susceptibility to Asthma, susceptibility to not specified Netherton syndrome
OMIM Allelic Variant UniProtKB (protein)
RCV000005585.2, RCV000005586.2, RCV000005587.2, RCV000248431.2, RCV000299337.1,
[PMID 16519819] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
[PMID 18704161] Genetic variation in an individual human exome.
[PMID 18774391] Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.