| Geno
|
Mag
|
Summary
|
| (A;A)
|
|
lowest IgE levels
|
| (A;G)
|
|
lower IgE levels
|
| (G;G)
|
0
|
normal but highest IgE levels
|
rs2427837 is a SNP in the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) on chromosome 1q23. High levels of serum IgE are associated with allergies, and are mediators of autoimmune diseases.
An examination of over 11,000 Germans led to the conclusion that rs2427837 (and one other FCER1A SNP, the tightly linked rs2251746) were strongly associated with high levels of serum IgE. The more common (G) allele was associated with higher serum IgE, and the effect appeared to be additive. Therefore, homozygous rs2251746(G;G) individuals may be at higher risk for atopic eczema and asthma than carriers of one or two (A) alleles. [PMID 18846228
]
[PMID 22222815] Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population
[PMID 24354852] A role of FCER1A and FCER2 polymorphisms in IgE regulation
[PMID 23725541] Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics.
[PMID 27746735] FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS.
]
