rs2472297

plus

Geno	Mag	Summary
(C;C)	0	common on affy axiom data
(C;T)	1.2	Associated with (slightly) increased coffee consumption
(T;T)	1.2	Associated with (slightly) increased coffee consumption

Reference

GRCh38 38.1/141

Chromosome

15

Position

74735539

is a	snp
is	mentioned by
dbSNP	rs2472297
dbSNP (classic)	rs2472297
ClinGen	rs2472297
ebi	rs2472297
HLI	rs2472297
Exac	rs2472297
Gnomad	rs2472297
Varsome	rs2472297
LitVar	rs2472297
Map	rs2472297
PheGenI	rs2472297
Biobank	rs2472297
1000 genomes	rs2472297
hgdp	rs2472297
ensembl	rs2472297
geneview	rs2472297
scholar	rs2472297
google	rs2472297
pharmgkb	rs2472297
gwascentral	rs2472297
openSNP	rs2472297
23andMe	rs2472297
SNPshot	rs2472297
SNPdbe	rs2472297
MSV3d	rs2472297
GWAS Ctlg	rs2472297

GMAF

0.1001

Max Magnitude

1.2

rs2472297 is a SNP located between the CYP1A1 and CYP1A2 genes on ch 15q24.

A meta-analysis of four GWAS studies of coffee consumption among a total of ~8,000 coffee drinkers of European ancestry found that the rs2472297(T) was strongly associated with increased consumption (p = 5.4 x 10e-14). The estimated effect was an increase of 0.2 cups a day per allele for both this SNP and one other (rs6968865).[PMID 21357676 ]

?

(C;C) (C;T) (T;T)

28

[PMID 25288136 ] Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.

[PMID 19479063 ] Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.

[PMID 20018080 ] Effects of covariates and interactions on a genome-wide association analysis of rheumatoid arthritis.

[PMID 21876539 ] Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.

[PMID 22854411] Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption

[PMID 23492908] Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure