rs2569190
| Orientation | plus |
| Stabilized | plus |
| Make rs2569190(A;A) |
| Make rs2569190(A;G) |
| Make rs2569190(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 140633331 |
| Gene | CD14, TMCO6 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2569190 |
| dbSNP (classic) | rs2569190 |
| ClinGen | rs2569190 |
| ebi | rs2569190 |
| HLI | rs2569190 |
| Exac | rs2569190 |
| Gnomad | rs2569190 |
| Varsome | rs2569190 |
| LitVar | rs2569190 |
| Map | rs2569190 |
| PheGenI | rs2569190 |
| Biobank | rs2569190 |
| 1000 genomes | rs2569190 |
| hgdp | rs2569190 |
| ensembl | rs2569190 |
| geneview | rs2569190 |
| scholar | rs2569190 |
| rs2569190 | |
| pharmgkb | rs2569190 |
| gwascentral | rs2569190 |
| openSNP | rs2569190 |
| 23andMe | rs2569190 |
| SNPshot | rs2569190 |
| SNPdbe | rs2569190 |
| MSV3d | rs2569190 |
| GWAS Ctlg | rs2569190 |
| GMAF | 0.4734 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs2569190, also known as C260T, is a SNP in the CD14 gene.
[PMID 18727828
] rs2569190(C) (frequency = 39%) increased stroke risk among smokers (OR = 2.05, 95% CI=1.09-3.86, p=0.03), but not among non-smokers (OR = 0.93, 95% CI=0.62-1.39, p=0.72)
[PMID 18417506] rs1295685 and rs20541 were significantly associated with elevated IgE levels in pooled analyses. rs2569190(T;T) and rs2569191(C;C) genotypes associated with lower IgE
A meta-analysis of 7 studies (comprising a total of 1488 patients and 1600 control subjects) found no significant association between rs2569190 and cerebrovascular diseases.[PMID 19433913]
[PMID 19468702] Functional impact of endotoxin receptor CD14 polymorphisms on transcriptional activity
[PMID 19701968] Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection
[PMID 19741468] Impact of Polymorphisms of TLR4/CD14 and TLR3 on Acute Rejection in Kidney Transplantation
[PMID 19830784] Association of CD14 variant with prostate cancer in African American men
[PMID 19968655] The role of lipopolysaccharide in the development of atopy in humans
[PMID 20109750] Host-microbial interactions in childhood atopy: Toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli
[PMID 22015088] CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma
[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 15867866] Polymorphisms in the 5' region of the CD14 gene are associated with eczema in young children.
[PMID 16614348] Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment.
[PMID 16759385] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).
[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
[PMID 16846490] Lemierre's syndrome and genetic polymorphisms: a case report.
[PMID 17062130] Polymorphisms within inflammatory genes and colorectal cancer.
[PMID 18987746] Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19337058] CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations.
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.
[PMID 19759553] Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.
[PMID 20398919] CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation?
[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
[PMID 21320344] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
[PMID 21333644] C(-260)T polymorphism in the promoter of CD 14 gene is not associated with myocardial infarction in the Tunisian population.
[PMID 21389010] Endotoxin exposure, CD14 and wheeze among farmers: a gene--environment interaction.
[PMID 21596674] Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico.
[PMID 21885391] Respiratory health and endotoxin: associations and modification by CD14/-260 genotype.
[PMID 21996339] Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies.
[PMID 22376040] Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.
[PMID 22494793] Innate immunity gene single nucleotide polymorphisms and otitis media
[PMID 23741383] CD14 -159 C>T Gene Polymorphism with Increased Risk of Tuberculosis: Evidence from a Meta-Analysis
[PMID 23349936] Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity
[PMID 24028589] TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk
[PMID 22749237] Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.
[PMID 23459936] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
[PMID 25394369] The Association of Polymorphisms of TLR4 and CD14 Genes with Susceptibility to Sepsis in a Chinese Population
[PMID 25000179] Genetic polymorphisms and sepsis in premature neonates
[PMID 25840711] Interactions between innate immunity genes and early-life risk factors in allergic rhinitis
[PMID 26174031] TLR4 Asp299Gly polymorphism may be protective against chronic periodontitis
[PMID 26462562] Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout
[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease
[PMID 27277665] Genetic risk factors for restenosis after percutaneous coronary intervention in Kazakh population.
[PMID 28829191] The CD14 rs2569190 TT Genotype is Associated with Chronic Periodontitis.
[PMID 29515128] The CD14 (-159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes.
[PMID 29687183] Single nucleotide polymorphisms of IL-13 and CD14 genes in allergic rhinitis: a meta-analysis.
[PMID 30288821] Early-life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitisation.
[PMID 30922395] Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis.
