rs279871
| Orientation | minus |
| Stabilized | minus |
| Make rs279871(A;A) |
| Make rs279871(A;G) |
| Make rs279871(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 46303716 |
| Gene | GABRA2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs279871 |
| dbSNP (classic) | rs279871 |
| ClinGen | rs279871 |
| ebi | rs279871 |
| HLI | rs279871 |
| Exac | rs279871 |
| Gnomad | rs279871 |
| Varsome | rs279871 |
| LitVar | rs279871 |
| Map | rs279871 |
| PheGenI | rs279871 |
| Biobank | rs279871 |
| 1000 genomes | rs279871 |
| hgdp | rs279871 |
| ensembl | rs279871 |
| geneview | rs279871 |
| scholar | rs279871 |
| rs279871 | |
| pharmgkb | rs279871 |
| gwascentral | rs279871 |
| openSNP | rs279871 |
| 23andMe | rs279871 |
| SNPshot | rs279871 |
| SNPdbe | rs279871 |
| MSV3d | rs279871 |
| GWAS Ctlg | rs279871 |
| GMAF | 0.4123 |
| Max Magnitude | 0 |
This SNP in the GABRA2 gene has been linked to Alcoholism.
The strongest association for this SNP is seen when it is a member of a haplotype consisting of the rs279871(A) + rs279845(T) + rs279836(A) alleles [PMID 15024690
].
[PMID 20698837] A Polymorphism in GABRA2 Is Associated With the Medial Frontal Response to Alcohol Cues in an fMRI Study
[PMID 18005236] Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression.
[PMID 18634760] Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.
[PMID 18727688] The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample.
[PMID 18781239] Multiple-domain predictors of problematic alcohol use in young adulthood.
[PMID 19487630] Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring.
[PMID 19783384] Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives.
[PMID 20133874] Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.
[PMID 21683760] Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence.
[PMID 23974430] Gender-Specific Gene-Environment Interaction in Alcohol Dependence: The Impact of Daily Life Events and GABRA2
[PMID 22817768] Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study.
| ClinVar | |
|---|---|
| Risk | rs279871(G;G) |
| Alt | rs279871(G;G) |
| Reference | rs279871(A;A) |
| Significance | Other |
| Disease | Alcoholism |
| Variation | info |
| Gene | GABRA2 |
| CLNDBN | Alcoholism, susceptibility to |
| Reversed | 1 |
| HGVS | NC_000004.11:g.46305733T>C |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000017605.3, |
[PMID 28847377] A GABRA2 polymorphism improves a model for prediction of drinking initiation.
