rs28365083

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(A;A)	2.5	CYP3A5*2 homozygote; nonexpressor for CYP3A5
(A;C)	2	carrier of one CYP3A5*2 allele
(C;C)	0	normal

Reference

GRCh38 38.1/141

Chromosome

7

Position

99652613

Gene	CYP3A5, ZSCAN25

is a	snp
is	mentioned by
dbSNP	rs28365083
dbSNP (classic)	rs28365083
ClinGen	rs28365083
ebi	rs28365083
HLI	rs28365083
Exac	rs28365083
Gnomad	rs28365083
Varsome	rs28365083
LitVar	rs28365083
Map	rs28365083
PheGenI	rs28365083
Biobank	rs28365083
1000 genomes	rs28365083
hgdp	rs28365083
ensembl	rs28365083
geneview	rs28365083
scholar	rs28365083
google	rs28365083
pharmgkb	rs28365083
gwascentral	rs28365083
openSNP	rs28365083
23andMe	rs28365083
SNPshot	rs28365083
SNPdbe	rs28365083
MSV3d	rs28365083
GWAS Ctlg	rs28365083

GMAF

0.001377

Max Magnitude

2.5

?	(A;A) (A;C) (C;C)	28

rs28365083, also known as 27289C>A, is a SNP in the CYP3A5 gene.

The rs28365083(A) allele defines the CYP3A5*2 variant, which is nonfunctional.

[PMID 17615053] Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.

[PMID 18547414] Genotyping panel for assessing response to cancer chemotherapy.

[PMID 19076156] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.

[PMID 20389299] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.