rs324650
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | |
| (A;T) | 0.1 | |
| (T;T) | 0.1 |
| Reference | GRCh38 38.1/141 |
| Chromosome | 7 |
| Position | 137008914 |
| Gene | CHRM2, LOC349160 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs324650 |
| dbSNP (classic) | rs324650 |
| ClinGen | rs324650 |
| ebi | rs324650 |
| HLI | rs324650 |
| Exac | rs324650 |
| Gnomad | rs324650 |
| Varsome | rs324650 |
| LitVar | rs324650 |
| Map | rs324650 |
| PheGenI | rs324650 |
| Biobank | rs324650 |
| 1000 genomes | rs324650 |
| hgdp | rs324650 |
| ensembl | rs324650 |
| geneview | rs324650 |
| scholar | rs324650 |
| rs324650 | |
| pharmgkb | rs324650 |
| gwascentral | rs324650 |
| openSNP | rs324650 |
| 23andMe | rs324650 |
| SNPshot | rs324650 |
| SNPdbe | rs324650 |
| MSV3d | rs324650 |
| GWAS Ctlg | rs324650 |
| GMAF | 0.4421 |
| Max Magnitude | 0.1 |
| ? | (A;A) (A;T) (T;T) | 28 |
|---|---|---|
|
| ||
In 2009, a large, multi-sample replication study failed to find any significant association with Intelligence for this or other SNPs in CHRM2 [PMID 19418213].
Earlier work had observed that this snp (and perhaps its neighbors) influenced intelligence and alcohol dependence
[PMID 16000316] CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. And the earlier [PMID 15229186]
[PMID 17160701] and [PMID 17081262] or this pdf poster show association between the CHRM2 gene and intelligence . In this study of ~300 Caucasians, the (T;T) genotype appeared to typically have a 4 point higher IQ than the (A;T) genotype, which had a 4 point higher IQ (on average) than the (A;A) genotype. A nearby SNP, rs324640, showed similar results to rs324650, and was in linkage disequilibrium (r2 = 0.90) with it. [PMID 17081262].
[PMID 19644963] Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction
[PMID 20351719
] Genetic variation in cholinergic muscarinic-2 receptor gene modulates M(2) receptor binding in vivo and accounts for reduced binding in bipolar disorder
[PMID 21176104] Association of CHRM2 polymorphisms with severity of alcohol dependence
[PMID 17373692] No evidence for association between 19 cholinergic genes and bipolar disorder.
[PMID 17996044] Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study.
[PMID 18634760] Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.
[PMID 19181679] Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.
