| Geno
|
Mag
|
Summary
|
| (A;A)
|
2
|
slight decrease in risk for Parkinson's disease
|
| (A;G)
|
2
|
slight decrease in risk for Parkinson's disease
|
| (G;G)
|
0
|
common
|
rs356168 represents a common SNP in an untranslated region of the SNCA gene on chromosome 4.
The rs356168(A) allele yields a slightly reduced risk for Parkinson's disease compared to the more common (G) allele.[PMID 25064009
]
An in vitro study of the effect of the rs356168(G) allele concludes it leads to increased transcription of the corresponding SNCA allele, which the authors feel is a credible explanation for the slight increase in risk for Parkinson's.[PMID 27096366]
[PMID 28979294] Interpreting Gene Expression Effects of Disease-Associated Variants: A Lesson from SNCA rs356168.
]
