rs356219
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal |
| (A;G) | 1.3 | 1.3x increased risk for Parkinson's disease |
| (G;G) | 1.6 | 1.6x increased risk for Parkinson's disease |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 89716450 |
| Gene | LOC105377329 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs356219 |
| dbSNP (classic) | rs356219 |
| ClinGen | rs356219 |
| ebi | rs356219 |
| HLI | rs356219 |
| Exac | rs356219 |
| Gnomad | rs356219 |
| Varsome | rs356219 |
| LitVar | rs356219 |
| Map | rs356219 |
| PheGenI | rs356219 |
| Biobank | rs356219 |
| 1000 genomes | rs356219 |
| hgdp | rs356219 |
| ensembl | rs356219 |
| geneview | rs356219 |
| scholar | rs356219 |
| rs356219 | |
| pharmgkb | rs356219 |
| gwascentral | rs356219 |
| openSNP | rs356219 |
| 23andMe | rs356219 |
| SNPshot | rs356219 |
| SNPdbe | rs356219 |
| MSV3d | rs356219 |
| GWAS Ctlg | rs356219 |
| GMAF | 0.4922 |
| Max Magnitude | 1.6 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs356219, a tagging SNP in the SNCA gene for a Parkinson's disease associated haplotype, predicts the amount of SNCA (alpha-synuclein) mRNA found in post mortem substantia nigra and cerebellum brain tissue. [PMID 18122487]
[PMID 21425343
] replicates the association of rs356219 with late-onset Parkinson's disease, calculating an odds ratio of 1.3 (CI: 1.13 - 1.5, p=2x10e-4) per rs356219(G) allele among the 1145 patients from northern Spain studied.
[PMID 18485051] Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population.
[PMID 21060011] SNCA Variant Associated With Parkinson Disease and Plasma {alpha}-Synuclein Level
[PMID 21159074] SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study
| GWAS snp | |
|---|---|
| PMID | [PMID 21292315]
|
| Trait | |
| Title | Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies |
| Risk Allele | G |
| P-val | 2E-47 |
| Odds Ratio | 1.2900 [1.25-1.33] |
[PMID 22349157] SNP rs356219 of the ?-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population
[PMID 22669510] Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants
| GWAS snp | |
|---|---|
| PMID | [PMID 22438815]
|
| Trait | |
| Title | Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. |
| Risk Allele | |
| P-val | 6E-65 |
| Odds Ratio | 1.2900 None |
[PMID 15637659] Linkage disequilibrium patterns and tagSNP transferability among European populations.
[PMID 17683088] Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.
[PMID 18162487] Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.
[PMID 18606870] Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.
[PMID 18985386] Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
[PMID 19063963] Genetic susceptibility in Parkinson's disease.
[PMID 19771175] Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.
[PMID 19834617] Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.
[PMID 21391235] Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.
[PMID 22425546] SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.
[PMID 23737253] SNCA rs356219 variant increases risk of sporadic Parkinson's disease in Ethnic Chinese
[PMID 23962496] The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
[PMID 23674386] SNCA: major genetic modifier of age at onset of Parkinson's disease.
[PMID 25656566] Alpha-synuclein (SNCA) polymorphisms and susceptibility to Parkinson's disease: A meta-analysis
[PMID 27538639] SNCA rs356182 variant increases risk of sporadic Parkinson's disease in ethnic Chinese.
[PMID 28676755] Variants in SNCA Gene Are Associated with Parkinson's Disease Risk and Cognitive Symptoms in a Brazilian Sample.
[PMID 30410434] A Comprehensive Analysis of the Association Between SNCA Polymorphisms and the Risk of Parkinson's Disease.
