rs3731239

minus

Geno	Mag	Summary
(C;C)		0.9x lower risk for breast cancer
(C;T)	0	?
(T;T)	0	normal risk

Reference

GRCh38 38.1/141

Chromosome

9

Position

21974219

Gene

CDKN2A

is a	snp
is	mentioned by
dbSNP	rs3731239
dbSNP (classic)	rs3731239
ClinGen	rs3731239
ebi	rs3731239
HLI	rs3731239
Exac	rs3731239
Gnomad	rs3731239
Varsome	rs3731239
LitVar	rs3731239
Map	rs3731239
PheGenI	rs3731239
Biobank	rs3731239
1000 genomes	rs3731239
hgdp	rs3731239
ensembl	rs3731239
geneview	rs3731239
scholar	rs3731239
google	rs3731239
pharmgkb	rs3731239
gwascentral	rs3731239
openSNP	rs3731239
23andMe	rs3731239
SNPshot	rs3731239
SNPdbe	rs3731239
MSV3d	rs3731239
GWAS Ctlg	rs3731239

GMAF

0.1988

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

rs3731239 shows a slight protective association against breast cancer in a British study involving ~2300 patients. The odds ratio for the (C;C) vs (T;T) homozygotes is 0.90 (CI: 0.79-1.03, p=0.013).[PMID 18174243 ]

[PMID 19258477 ] ovarian cancer rs3731239 rs602652 rs3212879 rs649392 rs3212891 rs2069391, rs2069414 rs17528736 rs3218036

[PMID 17459456 ] A common variant of the p16(INK4a) genetic region is associated with physical function in older people.

[PMID 19124506 ] Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.

[PMID 20018004 ] A search for non-chromosome 6 susceptibility loci contributing to rheumatoid arthritis.

[PMID 20386740 ] Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.

[PMID 23361049 ] Common genetic variants in the 9p21 region and their associations with multiple tumours

[PMID 25239644 ] Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers